Enlarged facial pores are common cosmetic concerns that are attributed to multiple factors. Excess sebum production, decreased skin elasticity, and increased hair follicle volume are the three main causes of enlarged pores. Other factors include sex, aging, excessive sun exposure and improper use of cosmetic products. 1 Due to great psychological impact, people have been trying to find treatment for this problem. Many treatment options are available including isotretinoin, chemical peeling, and laser therapy. 2Microbotox has been proved to be effective in improving the sheen and texture of the skin, as well as decreasing sweat and sebum production and enlarged pores as it causes atrophy of sebaceous glands, which subsequently causes tightening of the skin envelope. 3 Microneedles (MNs) can create hundreds of reversible microchannels in non-invasive manner to enhance transdermal drug delivery and promote collagen production. 4 Depending on the previously mentioned data, this study aimed to compare the efficacy and longevity of intradermal microbotox
Background Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin‐converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflammatory disorders. However, there are no studies investigating its association with AGA susceptibility. Objectives In this work, we aimed at exploring the association of ACE gene I/D polymorphism in AGA susceptibility in a group of Egyptian patients. Methods This study included 100 AGA patients, and 100 apparently healthy controls. The ACE gene I/D polymorphism was analyzed by polymerase chain reaction. Results The DD, ID genotypes, and D allele showed higher frequent distribution among studied AGA patients than controls (p < 0.05 each). Positive family history and ACE gene I/D polymorphism were considered AGA susceptibility predictors in both uni‐ and multivariable analyses [p < 0.05 each (OR (95% CI)] on applying logistic regression analysis for risk factors prediction. Conclusions This study highlights the possible contribution of the suspected genetic polymorphism as a susceptibility indicator for AGA development in the examined group of patients.
Objective This study aimed to assess the importance of male ejaculation on female satisfaction and orgasm. Background Although links between ejaculatory control or intravaginal ejaculatory latency time and female sexual function have been reported in the past, little research has focused on the effect of ejaculation on female satisfaction and orgasm. Methods The study was carried out on 221 of married women aged 18-50+ years. The tool used was a self-report questionnaire written in English and translated into Arabic. Results More intense orgasm and more satisfaction was reported by 58.4% of women if husbands ejaculated intravaginally without a condom. Among participants 47.1% didn’t perceive the quantity of husbands ejaculate as an expression of their own sexual attractiveness. Male condom was used by 34.8% of husbands and frequency of reaching orgasm was lower in women of these men. Although use of condom prolongs intravaginal latency time, 60% of participants were unsatisfied with their sexual life if husbands ejaculate in condom. The commonest coital frequency was once/week (45.2%). Dyspareunia was a complaint of 40.7% of participants. Coital frequency declined with advance in age, vaginal intercourse was the preferred sexual activity in almost all age groups and only 35.7% of the participants could reach orgasm in almost each intercourse most commonly because of life problems and work tensions Conclusion Intravaginal male ejaculation may give women more intense orgasm and satisfaction.
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