Gastric cancer is a malignant gastric mucosal cancer that often began on the side where the gastric layer is inflamed. Previous research has shown that high uric acid levels are associated independently with an increased risk of gastric cancer and it is suspected that there is a correlation between gastric cancer and elevated levels of uric acid levels but is still poorly known in detail. The aim of this study was to analyse the correlation between uric acid levels and stage of malignancy of gastric cancer patients in the oncology department of Mohammad Hoesin Hospital Palembang. This research was an analytic observational study by using a cross-sectional design to test the correlation between uric acid levels and stages of malignancy in gastric cancer. The results obtained was analyzed using Goodman and Kruskal’s Gamma correlation test. The Goodman and Kruskal’s gamma test results showed a strong correlation (p=0,033; r=0,746) between uric acid levels and which shows a significant correlation with 95% of confidence levels. Every increment in uric acid levels would be followed by an increase in stages of malignancy in gastric cancer.
Saat ini, akses masyarakat terhadap obat-obatan semakin mudah. Namun, hal tersebut tidak disertai dengan pemahaman yang benar terhadap obat-obatan. Akibatnya, hal tersebut menimbulkan berbagai masalah terkait obat seperti penggunasalahan dan pembuangan obat secara sembarangan. Oleh karena itu, masyarakat perlu diberi pengetahuan dan keterampilan yang benar tentang cara mendapatkan, menggunakan, menyimpan dan membuang obat (DAGUSIBU). Kegiatan pengabdian masyarakat ini berupa pendampingan dengan kegiatan utama penyuluhan dan demonstrasi tentang DAGUSIBU terhadap masyarakat di Kelurahan Keputeraan, Kota Lubuklinggau, Sumatera Selatan. Kegiatan diikuti oleh 34 orang peserta yang terdiri dari masyarakat dan kader kesehatan. Analisis keberhasilan kegiatan dilakukan dengan melakukan evaluasi sebelum dan sesudah penyuluhan. Dari kegiatan tersebut dapat diketahui bahwa hampir seluruh peserta tidak mengetahui tentang DAGUSIBU. Setelah diberikan penyuluhan dan demonstrasi, sebagian beserta dapat memamahi dengan baik dan memiliki keterampilan sederhana dalam DAGUSIBU. Dari hasil tersebut, diharapkan masyarakat dapat menerapkannya dalam kehidupan sehari-hari.Kegiatan pengabdian masyarakat berupa penyuluhan ini telah dapat meningkatkan pengetahuan dan keterampilan masyarakat dalam DAGUSIBU sehingga perlu diupayakan kegiatan yang berkesinambungan guna mencegah penggunasalahan obat dalam masyarakat. Kata kunci: DAGUSIBU, Obat, Pendampingan, Penyuluhan ABSTRACT Today, people's access to medicines is getting easier. However, this is not accompanied by a correct understanding of medicines. As a result, it raises various drug-related problems such as medicines abuse and indiscriminate disposal. Therefore, people need to be given the right knowledge and skills on how to get, use, store and dispose of medicines (DAGUSIBU). This community service activity is in the form of assistance with the main activities of counseling and demonstration about DAGUSIBU to the community in Keputeraan Village, Lubuklinggau City, South Sumatra. About 34 participants consisting of community members and health cadres attended the activity. Analysis of the success of activities carried out by evaluating before and after counseling. From these activities, it can be seen that almost no participants knew about DAGUSIBU. After being given counseling and demonstration, some of them along with be able to understand well and have simple skills in DAGUSIBU. From these results, it is expected that the community can apply it in everyday life. Community service activities in the form of counseling have been able to improve the knowledge and skills of the community in DAGUSIBU so that it needs to be pursued in a sustainable activity to prevent the use of drug problems in the community. Keywords: Assistance, Counseling, DAGUSIBU, Medicines
Carbapenemase enzymes play the most important role in the existence of CRE (Carbapenem-resistant Enterobacteriaceae). VIM is one of the carbapenemase enzymes encoded by the blaVIM gene. The genes which are partially located in genetic mobile elements may facilitate the spread of the resistance to other bacteria. The aim of this study was to identify the blaVIM gene in CRE isolated from infected patients in dr. Mohammad Hoesin Palembang. This descriptive observational laboratory study using 709 samples of Enterobacteriaceae isolated from various specimens of infected patients at dr. Mohammad Hoesin Palembang during the September-November period which would be identified as CRE using Vitek 2 Compact. 21 isolates which have been identified by CRE was taken by purposive sampling method to detect blaVIM gene with conventional polymerase chain reaction (PCR). The PCR product was electrophoresed and visualized to see a single 390bp DNA band. Out of 709 isolates of Enterobacteriaceae, 88 (12.4%) isolates were identified as CRE. Only 21 isolates of CRE performed PCR. Three (14.3%) isolates carrying the blaVIM gene which found in Enterobacter sp. (N=2; 66.7%) and Klebsiella pneumoniae (n=1; 33.3%). In this study 14.3%, Enterobacteriaceae with CRE phenotype has blaVIM gene genotype.
Background: Uric acid is generated from xanthine and hypoxanthine through the action of xanthine oxidase. Yellow wood contains flavonoids that inhibit xanthine oxidase activity. Objective: This study aims to determine the effectiveness of ethanol extracts of the leaves and stems of yellow wood in inhibiting xanthine oxidase. Methods: The leaves and stems of yellow wood were extracted with 96% ethanol. Xanthine oxidase activity was measured using UV Vis spectrophotometry at 293 nm at various doses of extracts, and inhibition was represented as the IC50 value. Control was performed with allopurinol. Results: Leaves and stems of yellow wood extract inhibited xanthine oxidase by 17.56% and 96.85% at 50 ppm, with IC50 values of 174.62 and 30.85, respectively. Conclusion: It demonstrates that stem extracts of yellow wood are more effective than leaves at inhibiting xanthine oxidase, lowering uric acid levels.
Penyakit diare merupakan masalah kesehatan masyarakat di negara berkembang seperti Indonesia, karena morbiditas dan mortalitasnya tinggi. Salah satu langkah dalam pencapaian target MDG’s adalah menurunkan kematian anak menjadi 2/3 bagian dari tahun 1990 sampai 2015. Studi mortalitas dan riset kesehatan dasar dari tahun ke tahun diketahui bahwa diare masih menjadi penyebab utama kematian balita di Indonesia. Penyebab utama kematian akibat diare adalah tata laksana yang tidak tepat baik di rumah maupun di sarana kesehatan.Penyuluhan kesehatan diharapkan dapat memberikan perubahan pengetahuan dan sikap ibu dalam penatalaksanaan balita dengan diare. Sehingga dapat menurunkan kematian balita akibat diare. Kegiatan berupa penyuluhan mengenai informasi tanda-tanda diare, penyebab diare, pencegahan dan penanganan diare. Selain itu diberikan brosur mengenai tanda-tanda bahaya diare serta pencegahannya. Selanjutnya dilakukan diskusi untuk mengevaluasi hasil penyuluhan.Sebanyak empat puluh dua warga dan tiga kader kesehatan mengikuti acara ini. Sebagian besar kader memiliki pengetahuan yang baik tentang diare dan penanganannya. Setelah dilakukan penyuluhan, semua warga semakin memahami cara pencegahan dan penanganan diare di rumah tangga. Warga juga memiliki kemampuan untuk mengenali tanda dan komplikasi diare, cara pencegahan diare dengan mencuci tangan menurut WHO dan cara pembuatan larutan gula garam serta cara pemberiannya.
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