The correlation between uric acid and stages of malignancy among gastric cancer patient in Palembang, Indonesia

Abstract

Gastric cancer is a malignant gastric mucosal cancer that often began on the side where the gastric layer is inflamed. Previous research has shown that high uric acid levels are associated independently with an increased risk of gastric cancer and it is suspected that there is a correlation between gastric cancer and elevated levels of uric acid levels but is still poorly known in detail. The aim of this study was to analyse the correlation between uric acid levels and stage of malignancy of gastric cancer patients in the oncology department of Mohammad Hoesin Hospital Palembang. This research was an analytic observational study by using a cross-sectional design to test the correlation between uric acid levels and stages of malignancy in gastric cancer. The results obtained was analyzed using Goodman and Kruskal’s Gamma correlation test. The Goodman and Kruskal’s gamma test results showed a strong correlation (p=0,033; r=0,746) between uric acid levels and which shows a significant correlation with 95% of confidence levels. Every increment in uric acid levels would be followed by an increase in stages of malignancy in gastric cancer.

Utility of serum and salivary lactate dehydrogenase and uric acid levels as a diagnostic profile in oral squamous cell carcinoma patients

“…[ 27 ] Studies have shown that high levels of serum uric acid are found to be associated with renal illness, cardiovascular disease, and metabolic syndrome, among other conditions. [ 25 26 ] Because of its inherent anti-oxidant properties, the levels of uric acid have also been investigated in various malignancies such as gastric cancer,[ 28 ] rectal cancer,[ 29 ] and head and neck cancer[ 30 ] and have been found to be elevated. However, other studies, pertaining to OC, have found the levels of uric acid to be decreasing.…”

The Adipokine Component in the Molecular Regulation of Cancer Cell Survival, Proliferation and Metastasis

“…A serum UA level above 358 µM was reported as the prospective risk factor in harboring prostate cancers [ 289 ]. Moreover, the survival rate of cancer patients with higher serum UA levels is reported as a potential indicator of poor prognosis and diminished survival rate in a number of malignancies such as renal [ 290 ], colorectal [ 291 ] gastric cancers [ 292 ] and osteosarcoma [ 293 ]. Now we focus on the possible underlying mechanism that could be attributed to the cancer-supportive nature of UA.…”