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1,2-Benzenedicarboxylic acid esters, commonly referred to as phthalate esters, form a group of compounds that are mainly used as plasticizers in polymers. Because phthalate esters are not chemically bound to the plastics, they can be released easily from products and migrate into the food or water that comes into direct contact. Due to their widespread use, they are considered as ubiquitous environmental pollutants. Phthalate esters are regarded as endocrine disrupting compounds by means of their carcinogenic effect. Phthalate esters can be analyzed by gas chromatography or high-performance liquid chromatography, however, their sensitivity and selectivity limit their direct use for determination of phthalates at very low level of concentrations exist in environmental samples with complex matrices. Therefore a sample pretreatment prior to their analysis is necessary. In this review, the historical development and overview of sample preparation methodologies have briefly been discussed and a comprehensive application of these methods in combination with different analytical techniques for preconcentration and determination of phthalate esters in various matrices have been summarized. Finally, a critical comparison of the different approaches in terms of enrichment factors achieved, extraction efficiency, precision, selectivity and simplicity of operation is provided.

A new and simple procedure has been developed for the indirect determination of amantadine in biological samples.

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