Development of dispersive liquid-liquid microextraction based on deep eutectic solvent using as complexing agent and extraction solvent: application for extraction of heavy metals

Sorouraddin, Saeed Mohammad; Farajzadeh, Mir Ali; Okhravi, Tohid

doi:10.1080/01496395.2019.1666874

Cited by 26 publications

(6 citation statements)

References 35 publications

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“…11,12 Scutellariae radix, a traditional Chinese medicine, belongs to the Labiatae perennial herb and is beneficial to reduce fever. 13 At present, more than 130 flavonoids have been found, and they have antipyretic, anti-inflammatory, antioxidant, immuneregulative, neuro-protective, and other pharmacological effects. As with most traditional Chinese medicines, the main extraction method of scutellariae radix is reflux with an organic solvent, which often has many disadvantages, including a long extraction time, a complex operation process, effective component reduction, and increased impurity contents.…”

Section: Introductionmentioning

confidence: 99%

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Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities

et al. 2020

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Deep eutectic solvents (DESs) play important roles in the extraction of active constituents in traditional Chinese medicine. Ultrasound-assisted DES has been used to extract flavonoids from Scutellaria baicalensis . Using the contents of scutellarin, baicalin, baicalein, wogonoside, wogonin, and oroxylin A as quantitative indices, different kinds of DESs have been optimized for extraction and betaine/acetic acid has shown the highest yield. The Box–Behnken response surface method (RSM) was utilized to select the extraction conditions with the highest yields. The optimal extraction conditions were as follows: the molar ratio of betaine/acetic acid was 1:4, the water content was 40%, the solid/liquid ratio was 1:100 g/mL, the extraction temperature was 52 °C, and the extraction time was 23 min. Compared with traditional reflux extraction using 70% ethanol as the solvent, ultrasound-assisted DES has a shorter extraction time and higher yields. Furthermore, anti-inflammatory activities of the two extracts by ultrasound-assisted DES and reflux were compared using RAW264.7 cells and the methyl thiazolyl tetrazolium (MTT) method, and they showed equal anti-inflammatory activities. The results demonstrated that the ultrasound-assisted DES method for extraction of flavonoids from scutellariae radix is simple, green, efficient, and reproducible. This research provides good method guides for the rapid and efficient extraction of flavonoids from natural sources.

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Section: Introductionmentioning

confidence: 99%

“…Scutellariae radix, a traditional Chinese medicine, belongs to the Labiatae perennial herb and is beneficial to reduce fever . At present, more than 130 flavonoids have been found, and they have antipyretic, anti-inflammatory, antioxidant, immune-regulative, neuro-protective, and other pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities

et al. 2020

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“…Analytical methods based on microextraction with eutectic solvents have also been used to quantify metals. In water samples, the following metals were analyzed: arsenic [211], cadmium [212], cobalt [213], copper [214], chromium [215][216][217], nickel [213,218], palladium [219] and selenium [220]. In the analysis of food and drinks, the eutectic solvents have been applied in the quantification of copper, cadmium and lead in honey and milk [221,222], copper in vegetables [223], chromium (VI)…”

Section: General Overview Of the Use Of Eutectic Solvents In The Deve...mentioning

confidence: 99%

A Review of the Use of Eutectic Solvents, Terpenes and Terpenoids in Liquid–liquid Extraction Processes

et al. 2020

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Diverse and abundant applications of the eutectic solvents have appeared in the last years. Their promising tunable properties, eco-friendly character and the possibility of being prepared from numerous compounds have led to the publication of numerous papers addressing their use in different areas. Terpenes and terpenoids have been employed in the formulation of eutectic solvents, though they also have been applied as solvents in extraction processes. For their hydrophobic nature, renewable character, low environmental impact, cost and being non-hazardous, they have also been proposed as possible substitutes of conventional solvents in the separation of organic compounds from aqueous streams, similarly to hydrophobic eutectic solvents. The present work reviews the application of eutectic solvents in liquid–liquid extraction and terpenes and terpenoids in extraction processes. It has been made a research in the current state-of-the-art in these fields, describing the proposed applications of the solvents. It has been highlighted the scale-up feasibility, solvent regeneration and reuse procedures and the comparison of the performance of eutectic solvents, terpenes and terpenoids in extraction with conventional organic solvents or ionic liquids. Ultimately, it has been also discussed the employ of predictive methods in extraction, the reliability of thermodynamic models in correlation of liquid–liquid equilibria and simulation of liquid–liquid extraction processes.

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“…The DLLME technique has many advantages, including simplicity, speed, cheap cost, ease of use, green solvent use, and high enrichment factors. Many improved liquid-phase microextraction (LPME) methods for Ni(II) separation and microextraction from diverse sources have recently been developed and described [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

An eco-friendly ultrasound-assisted deep eutectic solvent-based liquid–phase microextraction method for enrichment and quantification of nickel in environmental samples

Hameed

2022

J.Umm Al-Qura Univ. Appll. Sci.

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An eco-friendly and easy ultrasound-assisted liquid phase microextraction approach using deep eutectic solvent (UA-DES-LPME) was established to preconcentrate and separate trace amount of nickel (Ni(II)) in various environmental samples before flame atomic absorption spectrometric estimation. In this method, Ni(II) was complexed with 2-(benzothiazolyl azo) orcinol reagent. The impacts various parameters on the microextarction of Ni(II) was investigated. The calibration graph is linear in the range of 1–500 µg L−1 and limits of detection and quantification were determined as 0.27 and 0.90 μg L−1, respectively. The RSD% and preconcentration factor were 2.30% and 100, respectively. The analysis of certified reference materials demonstrated the validity of the established procedure. The microextraction method provided here simple, rapid, cheap, green and was effectively used to determine nickel levels in a variety of environmental samples with recoveries ranged of 95.0–98.54%.

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Development of dispersive liquid-liquid microextraction based on deep eutectic solvent using as complexing agent and extraction solvent: application for extraction of heavy metals

Cited by 26 publications

References 35 publications

Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities

Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities

A Review of the Use of Eutectic Solvents, Terpenes and Terpenoids in Liquid–liquid Extraction Processes

An eco-friendly ultrasound-assisted deep eutectic solvent-based liquid–phase microextraction method for enrichment and quantification of nickel in environmental samples

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