Osteoporosis (OP) has been observed to have a deleterious effect on postmenopausal women’s life quality by increasing the risk of fragility fractures. The current research was adopted to verify the role of serum adiponectin, a cytokine released by adipose tissue, as a marker for OP across different body mass index groups, for a better understanding of fatty tissue role in OP. A case-control study recruited 210 eligible postmenopausal women and subgrouped into three groups based on their DEXA scan results: osteoporotic group, osteopenia group, and healthy controls; each includes 70 patients. Three datasets were collected: anthropometric, age, menopause duration, weight, height, body mass index (BMI), waist circumference, and fat percentage. Radiological examination estimated the bone mineral density (BMD) for the femoral neck and lumbar spines with their respective T-score. From blood, we measured alkaline phosphatase and calcium by a spectrophotometer and serum adiponectin, phosphate, CTX, and PICP by ELIZA. Total BMD, T-score, serum phosphate, and PICP were significantly higher among healthy controls. Serum adiponectin, CTX, and ALP scored higher levels among OP cases. A strong inverse relationship was proved between serum adiponectin and T-score in osteoporotic and osteopenia groups (−0.427, −0.301). A strong negative relationship was found between serum adiponectin and total BMD in healthy controls (−0.204). All correlations were statistically significant, P value <0.001. Serum adiponectin can be a valuable marker for reduced bone mineral density among the general populace, irrespective of the body mass index. Further research is warranted to explore therapeutic and preventive applications for this adipocytokine.

The current study aimed to verify of irisin concentration in TIDM and the scan the association the irisin value with the physiological inflammatory parameters.The study included 60 individuals diagnosed in newly onset TIDM and 35 healthy individuals as acontrol group. IL-6 and C-reactive protein(CRP) concentration was calculated. Serum irisin level in addition to inflammatory factors were evaluated by ELISA kit.The results explained a sagnifecant increased at (P ≤ 0.05) in level of fasting blood sugar (FBS), HbA1C and irisin level in type I patients compared with the controlgroup, (7.95±2.024vs94±0.47mmol/dl, 6.91±1.094vs28±0.56mmol/dl, 33.38±7.ng/mlvs27.24±4.50ng/ml. respectively). So the results showed significantly decreased of BMI, C-peptide, Insulin and HOMO-IR level (p≤ 0.05) in GI contrast with control grouping (19.04±0.71 vs22.62±1.19, 0.21±0.02 vs 6.11±0.50, 0.19±0.04 vs 24.99±0.73, 0.06 ±0.02 vs5.49 ± 0.53 respectively). Investigation of lipid profile the results explained there was non-significant decreased of cholesterol (p≤ 0.05) in GI contrast with group’s control, but there was significant decreased of Tg, and HDL levels in GI contrast with group’s control, on the other hand the results showed a significant increase (p≤ 0.05) of LDL level in GI compared with control group(3.78±0.46vs3.96±0.46, 1.55±0.21 vs1.62±0.37, 1.02±0.15 vs1.52±0.37, 2.45±0.58 vs 2.11±0.45 respectively). The results of inflammatory parameters explained there was a significant increased (p≤ 0.05) of IL-6 and CRP levels in patients compared with control group (21.0±5.25vs12.79±0.93, 3.14±1.16 vs2.37±0.69 respectively) (Table 1). In TIDM grouped, iris in value showed negative association with (HbA1c) value (r=- 0.353, p<0.001), glucose (r=-0.290) and HOMO-IR(r=-0.232), cholesterol (r=-0.133), Tg, (r=-0.071-) and LDL(r=-0.163), So the correlation analysis explained a positive correlation with insulin level(r=0.055), C.peptide(r=0.105), HDL(r=0.229-), BMI(r=.115), IL-6(r=0.067), and CRP(r=0.171).

The present study aimed to assessment of irisin level in patients with the newly onset type 2 " diabetes mellitus " (T2D.M.) and the scanning the association of irisin value with some physiological and oxidant-anti oxidant parameters. This study comprised 60 individuals diagnosed in newly onset T2DM. and 40 healthy contributor (control group). Malondialdehyde (MDA), Ceruloplasmin and serum albuminconcentration was calculated in patient who involved in this study. Serum irisin levels was evaluated by ELISA kit.The present study showed a significant increasing (P ≤ 0.05) of glycohemoglobin (HbA1C) and FBS level in

The aim: To study the role of oxidative stress in patients with chronic kidney disease. Materials and methods: By evaluating MDA and GSH in the serum, we tried to find out how oxidative stress affects CKD patients with end-stage renal dysfunction (ESRD). The study included 90 patients with ESRD disease whom were under hemodialysis treatment, and 30 healthy control people. Results: Urea, creatinine, and MDA levels were noticeably greater in ESRD patients compared to controls, but GSH levels were noticeably lower. In conclusion, oxidative stress can cause more problems to these patients by its involvement in the appearance of metabolic and cardiovascular diseases. Conclusions: Furthermore, GSH was reduced significantly in ESRD patients and associated negatively with the level of MDA. This indicates the strong involve¬ment of antioxidants, especially GSH, in the development of oxidative stress in ESRD patients.