The present study aimed to assessment of irisin level in patients with the newly onset type 2 " diabetes mellitus " (T2D.M.) and the scanning the association of irisin value with some physiological and oxidant-anti oxidant parameters. This study comprised 60 individuals diagnosed in newly onset T2DM. and 40 healthy contributor (control group). Malondialdehyde (MDA), Ceruloplasmin and serum albuminconcentration was calculated in patient who involved in this study. Serum irisin levels was evaluated by ELISA kit.The present study showed a significant increasing (P ≤ 0.05) of glycohemoglobin (HbA1C) and FBS level in