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Introduction: Staphylococcus aureus is responsible for skin and soft tissue infections, surgical site infections. Macrolidelincosamide-streptogramin B (MLSB) antibiotics particularly clindamycin is favoured agent to treat skin and soft tissue infections cause by Staphylococcus aureus. Broad utilization of these antibiotics has prompted an expansion in resistance against these antimicrobials, requiring the need to recognize such resistance on routine premise utilizing a D test. Aims and Objectives: To study inducible clindamycin resistance & antimicrobial susceptibility pattern of S. aureus isolates. Materials and Methods: 300 isolates of S. aureus from different clinical examples were subjected to antimicrobial susceptibility testing by Kirby Bauer's disc diffusion method. Just erythromycin resistant isolates were subjected for D test to contemplate inducible clindamycin resistance according to CLSI guidelines. Results: Out of 300 isolates, 171 (57%) S. aureus isolates were erythromycin resistant. Among these isolates 84 (28%) showed MS phenotype, 68 (22.66%) showed inducible resistance & 19 (6.33%) showed constitutive resistance. Conclusion: A D test can be utilized to identify inducible clindamycin resistance. This test will help for legitimate treatment of the patients yet additionally counteract misuse of anti-microbial agents.

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