Exercise training after RTX results in higher levels of measured and self-reported physical functioning; however, exercise alone does not affect body composition.
Abstract. This study is an investigation of whether a protocol biopsy may be used as surrogate to late graft survival in multicenter renal transplantation trials. During two mycophenolate mofetil trials, 621 representative protocol biopsies were obtained at baseline, 1 yr, and 3 yr. The samples were coded and evaluated blindly by two pathologists, and Chronic Allograft Damage Index (CADI) score was constructed. At 1 yr, only 20% of patients had elevated (Ͼl.5 mg/100 ml) serum creatinine, whereas 60% of the biopsies demonstrated an elevated (Ͼ2.0) CADI score. The mean CADI score at baseline, 1.3 Ϯ 1
rATG with tacrolimus and MMF therapy may allow early elimination of corticosteroids, is associated with trends toward lower lipid levels, less weight gain, and a safety profile comparable to CCST therapy.
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