The Risk Of Transmission Of Hepatitis B From Hbsag(-), Hbcab(+), Hbigm(-) Organ Donors

Wachs, Michael; Amend, W; Ascher, Nancy L.; Bretan, Peter N.; Emond, Jean C.; Lake, John R.; Melzer, Juliet S.; Roberts, J.P.; Tomlanovich, S.; Vincenti, Flavio; Stock, Peter G.

doi:10.1097/00007890-199501270-00014

Cited by 320 publications

(114 citation statements)

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“…Our search strategy yielded 11 studies focusing on the safety of renal transplantation from HBcAb‐positive donors . Two studies were discarded because of insufficient presentation of data and duplicate publication of the same patients' data .…”

Section: Resultsmentioning

confidence: 99%

“…From them, 134 were excluded; 19 patients because of being HBsAg+ before transplantation, 106 cases because of insufficient data, 1 patient because of previous history of hepatitis B, 1 case because of simultaneous renal and pancreas transplantation, and 7 recipients for deaths from etiologies not related to kidney transplantation <1 year after transplantation. Table shows characteristics of included studies . All included studies were published as full text in peer‐reviewed journals between 1995 and 2007.…”

Section: Resultsmentioning

confidence: 99%

“…From a total of 1385 included kidney recipients, HBsAg seroconversion was reported only in 4 cases . One of these recipients was HBcAb seropositive before transplantation .…”

Section: Resultsmentioning

confidence: 99%

“…It has been previously shown that the infection rate from HBcAb‐positive kidney and heart allografts was significantly lower than that from liver allografts . The lower viral load in heart and kidney may explain the lower risk of HBV transmission through heart and kidney allografts.…”

mentioning

confidence: 98%

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Renal grafts from anti‐hepatitis B core‐positive donors: a quantitative review of the literature

Mahboobi

Tabatabaei

Blum

et al. 2012

Transplant Infectious Dis

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…From a total of 1385 included kidney recipients, HBsAg seroconversion was reported only in 4 cases . One of these recipients was HBcAb seropositive before transplantation .…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 98%

See 2 more Smart Citations

Renal grafts from anti‐hepatitis B core‐positive donors: a quantitative review of the literature

Mahboobi

Tabatabaei

Blum

et al. 2012

Transplant Infectious Dis

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“…Since 2 of these reactivated, they proposed that the risk of reactivation in this context was 5%. HBV can be also transmitted from anti-HBc-positive, HBsAg-negative organ donors (kidney, liver) recipients [30]. French et al [31] showed that 2% of women with isolated anti-HBc positivity acquired HBsAg positivity at a median of 7.5 years after their study entry.…”

Section: Discussionmentioning

confidence: 99%

Antibodies to Core Antigen of Hepatitis B Virus in Patients on Renal Replacement Therapy: Association with Demographic, Clinical and Laboratory Data

Grzegorzewska

Kurzawska-Firlej²,

Ratajewski³

et al. 2009

Nephron Clin Pract

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Background: Total antibodies to core antigen of hepatitis B virus (anti-HBc) are a marker for previous or current infection with hepatitis B virus (HBV). Our aim was to examine the prevalence and incidence of anti-HBc in relation to demographic, clinical and laboratory data of patients treated with intermittent hemodialysis (IHD). Methods: Predictors for anti-HBc positivity were evaluated in prevalence IHD patients with negative testing for surface antigen of HBV (HBsAg, n = 1,105) using the stepwise backward regression analysis. Patients starting IHD (n = 336) were introduced into the one-year prospective study evaluating seroconversion for anti-HBc. Results: Anti-HBc positivity (19.5% of all patients) was predicted by lack of vaccination against HBV with developed protective titer of antibodies to HBsAg (β = 0.592, p = 0.000), vintage of renal replacement therapy (RRT, β = 0.206, p = 0.000), history of hepatitis (β = 0.101, p = 0.000), and activity of alanine aminotransferase (β = 0.057, p = 0.037). In 85 prospective patients who finished first IHD year, seroconversion rate for anti-HBc was 1.23 episodes/100 patient-years. Conclusions: Lack of or not effective vaccination against HBV is the strongest predictor for prevalence of anti-HBc positivity in RRT patients. Periodical determination of anti-HBc, usually not required, may be helpful in evaluation of current epidemiological status and risk for further HBV infection in dialysis centers.

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De novo infection of hepatitis B virus in patients with orthotopic liver transplantation: Analysis by determining complete sequence of the genome

et al. 2000

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De novo infection of hepatitis B virus (HBV) occurs after liver transplantation from donors with HBV markers that suggest past infection. In the present study, the complete nucleotide sequences of HBV derived from a donor and recipients were determined to determine the clinical and virological characteristics. A total of 57 donor-recipient pairs, which underwent living-related orthotopic liver transplantation, were enrolled in the present study; all were negative for HBsAg before transplantation. HBV DNA was tested in serum, liver tissue, and peripheral blood mononuclear cells (PBMCs) by the polymerase chain reaction (PCR). The nucleotide sequence of HBV was determined based on PCR products and the phylogenetic analysis. De novo infection of HBV was found in 3 of the 57 recipients. Anti-HBc was positive in all donors of 3 recipients with the de novo infection but was positive only in 4 donors of the remaining 54 recipients (P=0.001). HBV DNA was detected in the liver but not in the serum or PBMCs in donor 3 whose recipient developed de novo HBV infection. The nucleotide sequence covering entire genome of HBV (3,215 bases) derived from the liver of donor 3 had a homology of 99.8-100% with that derived from the serum of corresponding recipient 3. The strain of recipient 3 showed the closest association with that of the donor 3 by phylogenetic analysis. Complete sequences from two recipients with de novo HBV infection including recipient 3 conserved the basic organisation of HBV genome. Analysis of the entire nucleotide sequence of HBV genome proved that HBV existed in the liver of the donor with anti-HBc, and it caused de novo infection in the corresponding recipient.

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The Risk Of Transmission Of Hepatitis B From Hbsag(-), Hbcab(+), Hbigm(-) Organ Donors

Cited by 320 publications

References 0 publications

Renal grafts from anti‐hepatitis B core‐positive donors: a quantitative review of the literature

Renal grafts from anti‐hepatitis B core‐positive donors: a quantitative review of the literature

Antibodies to Core Antigen of Hepatitis B Virus in Patients on Renal Replacement Therapy: Association with Demographic, Clinical and Laboratory Data

De novo infection of hepatitis B virus in patients with orthotopic liver transplantation: Analysis by determining complete sequence of the genome

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