Natural resources and traditional medicines are important assets that need to be explored, researched, developed and optimized for their use. One of the natural resources that can be used as medicinal ingredients is chives (Allium schoenoprasum, L.), especially the leaf. Chives leaf contained a lot of phytochemical compounds which is potential as an antioxidant and antilithogenesis. The objective of this research is to evaluate the antioxidant and antilithogenesis activities of chives leaf extract. Antioxidant activity was evaluated by using DPPH as a free radical scavenging method. Total phenol and total flavonoid content also determined by using Folin-Ciocalteu and aluminum chloride colorimetric assay. Antilithogenesis assay was measuring using atomic absorption spectrophotometry method by incubating the kidney stone using extracts of chives leaves at 37 o C for 6 hours. The measurement of calcium was using acetylene-air flow at 422.7 nm wavelength. From the data obtained, the highest antioxidant activity was found in ethyl acetate extract (IC50: 236.51±0.08 ppm). The highest phenolic content was found in the ethanolic extract (111.28±1.29 mg/g extract) while the total flavonoid was found in ethyl acetate extract (34.64±1.60 mg/g extract). While, antilithogenesis activity showed that the best result was using 2.5% (E5) concentration with 95.55% solubility of calcium which obtained from ethyl acetate extract.Based on the above results, it can be concluded that chives leaf extracts have a potential and promising as an antioxidant and antilithogenesis sources
The synthetic drugs for DM treatment are available in the market, but they have side effects in long term treatment. This makes a research about effective natural resources to reduce diabetes intensity are rampant, one of them is Coriander leaf (Coriandrum sativum L). Ethanolic extract of coriander leaf (EECL) was tested for phytochemical screening and anti-diabetic activity, by glucose tolerance test in normal rats and alloxan-induced diabetic mice. The mice were divided into five groups of six animals each (diabetic control, standard drug-treated, and plant treated groups (100, 20 and 400 mg/kg bw)). On the 0 th , 3 th , 6 th , 9 th , 12 th and 15 th days, the blood samples were analyzed for blood glucose.The results of phytochemical screening showed that EELC has a lot of phytochemical compounds such as alkaloids, flavonoids, tannins, glycosides, saponins and steroids. Antihyperglycemic study showed that there were not have significant differences between EECL and metformin 65 mg/kg bw group. Based on the research investigation, it can be concluded that EELChas an antihyperglicemia effect.
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