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Novel Aryloxyalkylthioimidazoles as Inhibitors of Acyl-CoA: Cholesterol-O-acyltransferase. -Various title compounds like (III), (V), and (VII) are evaluated for their ability to interfere with the enzyme acyl-CoA. Most of them show a good in vitro ACAT inhibitory activity. (III) and (Va) reduce low density lipoprotein cholesterol levels and increase high density lipoprotein cholesterol levels. -(BANI, M.; BORMETTI, R.; CEC-CARELLI, W.; FIOCCHI, R.; GOBETTI, M.; LOMBROSO, M.; MAGNETTI, S.; OLGIATI, V.; PALLADINO, M.; VILLA, M.; VANOTTI, E.; Eur.
Agents. -The title compounds (IV), (VI) and (VIII) are found to show good hypolipemic activity, significant increase of HDL cholesterol and no hepatotoxicity. -(VANOTTI, E.; BANI, M.; FAVARA, D.; GOBETTI, M.; LOMBROSO, M.; MAGNETTI, S.; OLGIATI, V.; PALLADINO, M.; TONON, G. C.; Eur.
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