The improved synthesis of 1H-imidazo[l,2-b]pyrazole 1 and of mono- and disubstituted derivatives is described and representative experimental procedures are given. Namely, 2-, 3-, 7- and 6-monosubstituted (2-15k), 2,3- and 6,7- disubstituted (16,17) compounds are prepared and characterized
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract The key step in the synthesis sequence shown in the scheme for the (S) enantiomer (VIII) of P-0160, an aryloxypropanolamine cardioselective β-blocker, is the reaction of the dioxolane (R)-(IV) with HBr in AcOH to give the acetoxy-bromo derivative (R)-(V). -Analogously, the (R) enantiomer of (VIII) is obtained starting from the (S) enantiomer of (I).
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis of pyrazoles.-General pharmacological screening of the title compounds does not show any significant biological activity for the novel pyrazoles,
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.