These results suggest that moderately intense exercise increases the phagocytosis of Kupffer cells, and that it might be induced by endotoxemia of portal blood caused by intestinal mucosal lesions resulting from acute exercise.
The effect of voluntary exercise on maximal oxygen uptake (VO2 max) was studied in young female Fischer 344 rats. After 10 weeks of wheel-running training, the absolute VO2 max and VO2 max relative to body mass increased without a decline in body mass. The running speed eliciting VO2 max, heart and soleus muscle mass, and succinate dehydrogenase (SDH) activity in the soleus muscle also increased. These results suggest that voluntary exercise is an effective means of increasing the aerobic exercise capacity of young female Fischer 344 rats.
These results suggested that hepatocytes suffered damage after high-intensity exercise, although these histochemical findings in the liver were not observed immediately after the exercise. In addition, in the case of physical activity, there might not be an intimate relationship between the release of enzyme as a hepatic functional biomarker and hepatocyte damage.
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