Effects of acute moderate exercise on the phagocytosis of Kupffer cells in rats

Yano, Hiromi; Kinoshita, S.; Kira, Shohei

doi:10.1111/j.1365-201x.2004.01343.x

Cited by 23 publications

(24 citation statements)

References 32 publications

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“…This is contrary to previous claims that monocyte-phagocyte system is depressed by CO 2 insufflation due to pH alterations [51,52]. Although it is not possible to directly prove with in vivo microscopy that the observed latex beads are taken up only by Kupffer cells, it has been demonstrated that these particles are phagocytized exclusively by Kupffer cells [53] and has been confirmed most recently with electron micrographs by Yano et al [54]. In their study no latex particles of different sizes were taken up by the sinusoidal endothelial cells of the rat liver.…”

Section: Discussioncontrasting

confidence: 77%

Signs of reperfusion injury following CO2 pneumoperitoneum: an in vivo microscopy study

et al. 2007

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Section: Discussioncontrasting

confidence: 77%

Signs of reperfusion injury following CO2 pneumoperitoneum: an in vivo microscopy study

et al. 2007

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“…It must be noted, however, that serum CK activity reflects both efflux into and clearance from the circulation. There are data in intact rat muscle that demonstrate CK efflux from muscle cells exposed to exercise [4, 7], but it is known that exercise also affects clearance of CK from the serum by immune cells such as the mononuclear phagocyte system [38]. Though the present data cannot distinguish efflux from clearance, they demonstrate a clear association between chronic exercise training and increases in serum CK activity in ovulating women.…”

Section: Discussioncontrasting

confidence: 40%

Serum Creatine Kinase Activity Varies with Ovulatory Status in Regularly Exercising, Premenopausal Women

2006

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Background/Aims: The clinical complications associated with an unopposed estrogen environment and luteal phase defects observed in exercising women prompted the examination of the relationship of exercise and endogenous ovarian steroids with serum creatine kinase (CK) activity. Methods: Subjects (n = 34) were classified into three groups according to their exercise and menstrual status, sedentary and exercising ovulatory groups (SedOvul, ExOvul), and an exercising amenorrheic group (ExAmen). Daily urine samples were collected to assess urinary ovarian steroid exposure and menstrual status. Serum CK activity was assayed in each menstrual cycle of all subjects. Results: Exercise increased serum CK activity in all exercising subjects (p < 0.01), but the increase was greater in amenorrheic women compared to ovulatory women (SedOvul: 33.0 ± 3.4; ExOvul: 43.7 ± 4.1; ExAmen: 54.4 ± 3.6, p < 0.05). When the ovulatory women were further divided into those with normal steroid production (ExOvul subgroup) and those with a suppressed progesterone luteal phase environment (ExLPD), both the ExOvul (51.9 ± 5.4 IU/l) subgroup and ExAmen group had higher serum CK activity (p < 0.05) than the ExLPD (36.6 ± 5.2 IU/l) subjects or the sedentary controls. Conclusions: These data demonstrate the complex association between ovarian hormone status and the normal serum CK response to regular mechanical stress imposed by chronic exercise training.

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“…In our experiment, a decreasing percentage of moving latex beads (i.e., an increasing percentage of adherent latex beads) was observed over a 5-min postperfusion interval. Although it is not possible to directly prove with in vivo microscopy that the observed adherent latex beads are taken up only by KCs, Widmann et al [27] have demonstrated that these particles are phagocytized exclusively by KCs; this finding was further documented by means of electron micrographs recently [28] . Our observation of increased KC phagocytic activity following warm ischemia/reperfusion seems to be in contrast to the findings of Vollmar et al [29] who suggested that prolonged warm ischemia/reperfusion of the liver depresses KC phagocytic activity; however, their observation took place some 60 min after reperfusion in contrast to our data which have been obtained much earlier after reperfusion.…”

Section: Discussionmentioning

confidence: 95%

Taurine Protects from Liver Injury after Warm Ischemia in Rats: The Role of Kupffer Cells

et al. 2007

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Background/Aims: Warm ischemia to liver with subsequent Kupffer cell-dependent pathology is associated with many clinical conditions. Taurine prevents Kupffer cell activation and improves graft survival after experimental cold ischemia and liver transplantation. Thus this study was designed to assess its effects after warm hepatic ischemia. Methods: The left liver lobe of female Sprague-Dawley rats (170–210 g) underwent 60 min of warm ischemia. Animals were given either intravenous taurine or Ringer’s solution 10 min prior to warm ischemia. Transaminases, histology, in vivo microscopy, intercellular adhesion molecules-1 (ICAM-1) expression, TNF-α and tissue hydroperoxide were compared between groups using analysis of variance (ANOVA) or ANOVA on ranks as appropriate. Results: Taurine significantly decreased transaminases and improved histologic outcome. Phagocytosis of latex beads, serum TNF-α levels and tissue hydroperoxide concentrations were also significantly reduced. Stickers in sinusoids and post-sinusoidal venules significantly decreased. In parallel, both leukocyte infiltration and ICAM-1 expression decreased (p < 0.05), while flow velocity of red blood cells as well as sinusoidal perfusion rate were improved (p < 0.05). Conclusion: This study demonstrates that taurine blunts Kupffer cell-dependent hepatic pathology after warm ischemia in vivo via mechanisms including leukocyte-endothelial interaction, microcirculation disturbances and protection against lipid peroxidation.

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Effects of acute moderate exercise on the phagocytosis of Kupffer cells in rats

Abstract: These results suggest that moderately intense exercise increases the phagocytosis of Kupffer cells, and that it might be induced by endotoxemia of portal blood caused by intestinal mucosal lesions resulting from acute exercise.

Cited by 23 publications

References 32 publications

Signs of reperfusion injury following CO2 pneumoperitoneum: an in vivo microscopy study

Signs of reperfusion injury following CO2 pneumoperitoneum: an in vivo microscopy study

Serum Creatine Kinase Activity Varies with Ovulatory Status in Regularly Exercising, Premenopausal Women

Taurine Protects from Liver Injury after Warm Ischemia in Rats: The Role of Kupffer Cells

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