Abstract. Assessment of substituent effects in a series of aryl imines through spectral correlation has been studied since they have close pharmacological association with diverse pharmacological properties. A series of aryl imines have been synthesized from 3-Nitro aniline with various substituted benzaldehydes were refluxed for 4h with 20 mL of absolute ethanol. The purity of all imines has been checked using their physical constants and spectral data. The UV λmax(nm), infrared νC=N(cm -1 ), NMR δ(ppm) of CH=N and C=N spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The single parameter correlation with few Hammett constants and F and R parameters gave satisfactory correlation coefficients whereas all multiple correlations gave satisfactory correlation coefficients with Resonance, Field and Swain-Lupton's parameters. The antimicrobial activities of all imines have been studied using Bauer-Kirby method. Aryl imine compounds with 2-Cl, 4-Br and 2-OCH 3 substituents have shown good antibacterial activity against S.aureus and those with 3-NO 2 and 4-NO 2 substituents have shown good antifungal activity against T.viridi.,
A series of aryl chalcones have been synthesized from 4-phenoxyacetophonone with various substituted benzaldehydes. The purity of all chalcones has been checked using their physical constants and spectral data. These spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The single parameter correlation with few Hammett constants and F and R parameters gave satisfactory correlation coefficients whereas all multiple correlations gave satisfactory correlation coefficients with Resonance, Field and Swain-Lupton's parameters. The antimicrobial activities of all chalcones have been studied using Bauer-Kirby method.
A series of 2,4-dimethoxy phenyl chalcones have been synthesized by Crossed-Aldol condensation of 2,4-dimethoxy phenyl and various substituted benzaldehydes. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalcones have been evaluated using Bauer-Kirby method.
Some 2′,3′,4′-trichlorophenyl chalcones [(E)-1-(2,3,4-trichlorophenyl)-3-(substituted phenyl)-2-propen-1-ones] have been synthesised using sulfated Titania catalyzed solvent-free aldol condensation between 2,3,4-trichloroacetophenone and substituted benzaldehydes. The purities of synthesised chalcones were checked by their analytical, physical and spectroscopic data reported in literature. The insect antifeedant activities of these chalcones have been studied using 4 th instar larvae Achoea Janata L by castor leaf disc bio-assay method. The chloro substituted chalcones shows significant insect antifeedant activity.
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