A patch type non-enzymatic free-cholesterol sensor was newly developed for continuous monitoring by using stainless steel based micro-needle patch and nanoporous platinum (NPt) sensing electrodes. The formed micro-needle patch was coated with parylene/gold/parylene film and selectively dry-etched to form the gold electrodes at the tips of microneedles. The bare gold tips were finally electroplated with nanoporous platinum. The sensor was then characterized and analyzed by using cyclic voltammetry and chronoamperometry measurement techniques. The fabricated sensor exhibited high sensitivity of 305nA/mM•cm 2 and correlation coefficient of 0.964 in 0.1M PBS (pH 7.4). In the recovery test, recovery rate was more than 89%.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.