The research objective was to study the association of the AGT rs699 missense SNP with arterial hypertension (AH) and metabolic risk factors among indigenous people of the Arctic territory of Yakutia. The obtained data show that representatives of indigenous people of the Arctic territory of Yakutia with the homozygous GG genotype for the AGT SNP rs699 are characterized by high levels of systolic blood pressure. The carriage of the GG genotype in AH patients is associated with a high frequency of hypo-HDL cholesterolemia. The carriage of GG genotype in AH patients, compared to subjects without AH, is characterized by higher blood levels of total cholesterol, LDL-C, and triglycerides and is associated with a high frequency of abdominal obesity. Thus, the AGT rs699 missense SNP was found to be associated with metabolic risk factors in indigenous AH persons of the Arctic territory of Yakutia.
The research objective was to study the association of the ACE gene I/D polymorphism with essential hypertension (EH) and metabolic risk factors among indigenous people of the northern territory of Yakutia. The obtained data show that representatives of indigenous people of the North of Yakutia with the ACE ID genotype are characterized with high levels of systolic blood pressure. The carriage of DD genotype in EH patients was associated with a high frequency of hypercholesterolemia and hyper-LDL cholesterolemia. The carriage of ID genotype in EH patients, compared to subjects without EH, was characterized by higher blood levels of TC, LDL-C, TG, and FPG and associated with a high frequency of obesity. Thus, the ACE I/D polymorphism was found to be associated with metabolic risk factors in indigenous EH patients of the North of Yakutia.
Background:The objective of our research was to study the ethnic-related characteristics of lipid and carbohydrate metabolism in the indigenous population of Yakutia.Methods and Results: The study was conducted under expeditionary conditions in the North of Yakutia (Nizhnekolymsky, Anabarsky, Verkhnekolymsky, Tomponsky, and Srednekolymsky districts). In total, 529 people aged between 20 and 70 years were examined in the primary health care units. For a comparative analysis, we formed 6 ethnic groups (Yakuts, Evenks, Evens, Dolgans, Chukchi, Yukagirs). In all ethnic groups, there was a high prevalence of atherogenic dyslipidemia, with the highest frequency in Evenks and Yakuts. Women had a higher frequency of lipid metabolism disorders than men did. The frequency of hyperglycemia was significantly higher among the Dolgans, Evenks and Yakuts than in other ethnic groups.Conclusion: This study showed a high frequency of metabolic syndrome in the examined ethnic groups, which is caused by a change in the traditional lifestyle and the nature of nutrition.
This pilot research was one of the first sociological studies with general questions on genetic testing with 300 participants, 75% of which were representatives of one people -the Sakha. A quantitative method was used: a sociological survey with quota sampling (Δ ± 5%), held in February -March 2018 in the City of Yakutsk (n = 350).Analysis of the survey results have shown that the respondents have low levels of awareness about the DNA-testing method: 72.3% "do not know about the method". Only 18.7% of respondents knew that since 2000 the Medical-Genetic Centre of the Sakha Republic (Yakutia) conducts DNA diagnostics for hereditary diseases, with 81.0% replying that they didn't know that. The questionnaire has shown that 90.3% of participants would like to undergo DNA-testing to identify their susceptibility to genetic diseases. Our questionnaire has shown high levels of self-identity among the young Sakha and their desire to learn about their belonging to a specific ethnicity (49.3%) with the assistance of DNA-testing. Furthermore, based on the answers relating to motivations for undergoing DNA-testing, we can say that the respondents have confirmed the peculiarities of their national mindset, specifically, high value of children for a family: "concern for the health of my future children" was a great motivator for taking the test (50.3%).
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