Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia

Abstract

The research objective was to study the association of the ACE gene I/D polymorphism with essential hypertension (EH) and metabolic risk factors among indigenous people of the northern territory of Yakutia. The obtained data show that representatives of indigenous people of the North of Yakutia with the ACE ID genotype are characterized with high levels of systolic blood pressure. The carriage of DD genotype in EH patients was associated with a high frequency of hypercholesterolemia and hyper-LDL cholesterolemia. The carriage of ID genotype in EH patients, compared to subjects without EH, was characterized by higher blood levels of TC, LDL-C, TG, and FPG and associated with a high frequency of obesity. Thus, the ACE I/D polymorphism was found to be associated with metabolic risk factors in indigenous EH patients of the North of Yakutia.

Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population

“…A number of important research papers have extensively searched the link of ACE I/D and AGT M235T with several diseases, mainly hypertension 22,10 and diabetes, [23][24][25] often with highly inconsistent findings throughout various ethnic populations worldwide; associations with overweight and obesity, an important risk factor for cardiovascular diseases, have also been reported. 9,26,27 In this context, ACE I/D and AGT M235T polymorphisms association studies in the Tunisian population are very limited, with reports linking them to obesity.…”