R: substituted phenyl, R 1 : H, CH 3 .
Abstract A facile and highly efficient method for the regioselective one-pot synthesis of a series of novel 1-(substituted phenyl)-2-(4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl)ketones from 2-bromo-1-(substituted phenyl)ketones, sodium azide, and trimethylsilyl acetylene, through Cu (I) catalyzed 1,3-dipolar [3+2] cycloaddition reaction is reported. The reaction proceeds smoothly in 40% aqueous
Vinylsilanes in Synthesis: 2-Halo-1-cyclopentenyl Alkyl/Aryl Ketones from 2-Halo-1-trimethylsilylcyclopentenes.-2-Halo-1silylcyclopentenes (II) smoothly undergo Friedel-Crafts acylation to produce the halocyclopentenyl ketones (IV) in good to high yield. -(PRASAD, S. H.; NAGENDRAPPA, G.; Indian J.
Hypervalent iodine (HVI) reagents are employed in organic synthesis as versatile, proficient, and environmentally friendly reagents. Despite the utility of such reagents, the application of HVI reagents, especially phenyliodonium diacetate (PIDA), has been limited due to its poor solubility in a myriad of solvents. The aggregated and polymeric structures of many HVI reagents account for their poor solubility, thus limiting the reactivity and use of HVI reagents in reactions in non-polar solvents. The research presented herein outlines ligand exchange reactions of universal carboxylic acids promoted by phenyliodonium diacetate (PIDA) reagents, in which the acetate moiety of PIDA is modified, ultimately enhancing the solubility and reactivity of HVI reagents.
Preparation of Amino Substituted Cyclic Vinylsilanes by Wurtz-Fittig Procedure. -2-Halo-3-morpholinocycloalkenes (I) can be silylated to give the corresponding 2-trimethylsilyl-substituted compounds (III) without cleavage of the C-N-morpholinyl bond using excess chlorotrimethylsilane and sodium. -(HARI PRASAD, S.; NAGENDRAPPA, G.; Indian J.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.