ChemInform Abstract: Preparation of Amino Substituted Cyclic Vinylsilanes by Wurtz—Fittig Procedure.

Abstract

Preparation of Amino Substituted Cyclic Vinylsilanes by Wurtz-Fittig Procedure. -2-Halo-3-morpholinocycloalkenes (I) can be silylated to give the corresponding 2-trimethylsilyl-substituted compounds (III) without cleavage of the C-N-morpholinyl bond using excess chlorotrimethylsilane and sodium. -(HARI PRASAD, S.; NAGENDRAPPA, G.; Indian J.

A Novel Regiospecific Synthesis of 1-Chloro-2-arylcyclohexenes

“…We employ the Wurtz-Fittig coupling reaction of corresponding cyclic vinyl halide with sodium and chlorotrimethylsilane in suitable solvent to prepare the cyclic vinylsilanes. Using the Wurtz-Fittig reaction, we have been able to synthesize a large number of simple and substituted cyclic vinylsilanes [15][16][17][18][19]. The organosilicon compounds are anionic synthons serving as the starting materials in the total synthesis of natural products [20][21][22][23].…”