Nowadays the diabetes mellitus has epidemic character. That’s why searching and creating of new medicines for effective therapy of this pathology are actual. Phytotherapy is one of the components in the complex treatment of diabetes mellitus type 2. It combines a wide range of pharmacological actions, fewer side effects and toxic reactions on the human body than synthetic drugs. Plants of genus of Portulaca L. can be perspective sources for searching new medicinal plants. Purslane (Portulaca oleracea L.) is used in folk medicine as hypoglycemic agent. The aim of the research was to study the hypoglycemic activity of the infusion of Portulaca oleracea herb. Simulation of insulin resistance was performed with intramuscular injections of glucocorticoids (Dexamethasone, 0.125 mg/kg). Portulaca oleracea infusion administered orally at the dose 10 ml/kg. Gliclazide freshly suspension was used as a reference drug and it was administered orally by 50 mg/kg. Characteristic of glucose homeostasis was carried out using a short insulin test, oral glucose tolerance test. Also assessed the effect of Portulaca oleracea infusion and reference drug on adrenaline hyperglycemia. Glucose level at 30 minutes after administration of insulin in the group that received Portulaca oleracea infusion reduced on 53.9%. There was a decrease on 37.5% in the group of diabetic control, and in the intact group – on 60.2%. The result of oral test of glucose tolerance showed that the area under the glycemic curve in groups that received Portulaca oleracea infusion (314.9 mmol/L·min) and reference drug Gliclazide (376.0 mmol/L·min) did not significantly differ from the similar area of the intact group (372.7 mmol/L·min). The administration of the epinephrine hydrochloride solution caused a sharp and significant increase in the glucose level in the diabetic control group. 90 minutes after the epinephrine injection the glucose level in animals which received Portulaca oleracea infusion increased in 3.15 times, and in the reference-group – in 1.97 times, which significantly differs from the diabetic control group. The obtained results indicate that the infusion of Portulaca oleracea herb reduce the formation of insulin resistance and glucose tolerance in the conditions of experimental dexamethasone diabetes mellitus in rats.
Atherosclerosis is recognized as "non-infectious pandemic of the XXI-th century". There is a wide range of drugs for correction of hyperlipidemia, as well as for the primary and secondary prevention of atheAtherosclerosis is the traditionally known consequence of the lipid metabolism disorders (dyslipidemia, hyperlipidemia, hypertriglyceridemia) and reduction of the elasticity of vessels of different caliber [4]. Hyperlipidemia is the major risk factor for atherosclerosis. Other complications are coronary heart disease, ischemic cerebrovascular disease, hypertension, obesity and diabetes mellitus (Type II). Although many effective lipid-lowering synthetic drugs exist, none is effective for all lipoprotein disorders, and all of them are associated with some adverse effects. Therefore, it is a need of the day to search other products from natural sources that are less toxic, less expensive, and can provide better safety and efficacy when using. Natural products from plants are a rich source used for centuries to cure various ailments [12].Today, a lipid-lowering therapy uses a wide range of drugs (statins, fibrates, cholesterol absorption inhibitors, niacin drugs) for correction of hyperlipidemia, as well as the primary and secondary prevention of atherosclerosis complications [5]. The known lipid-lowering drugs have many side effects in patients [11].Herbal medicines have several advantages over synthetic monodrugs. In particular, due to the complex and balanced chemical composition and the rational combination of biologically active substances they have multifaceted effects on the body: on the one hand, they affect directly on the diseased area, and on the other hand, provide pharmacological correction of various functional systems [3,13]. In this regard it is interesting to study triterpenoid compounds isolated from the plant material, which have a wide range of pharmacological activities, including the lipid-lowering effect [1,10]. The Rosaceae family includes such interesting species as Poterium polygamum Waldst. Et Kit., P. sanguisorba L., P. lasiocarpum Boiss. Et Hausskn., which are widespread in Ukraine. Such triterpenoids as caccigenin, poteriside and tormentoside are contained in the underground part of these plants [6].The aim of this study was to assess the antihyperlipidemic properties of the ethanol extract of P. sanguisorba L. (burnet salad) on the model of acute hyperlipidemia. Materials and MethodsOnly male albino Wistar rats weighing 200-220 g were used in this study. They were acclimatized under laboratory conditions. Animals were fed on a standard diet and water ad libitum. Thirty animals were distributed into 5 groups (six rats in each group): Group 1 -control rats, group 2 -intact rats, group 3 -standard rats, group 4-5 -test rats.P. sanguisorba L. rhizomes were collected in the Zaporizhzhia region, dried under shade, powdered and extracted with 96% ethanol in a Soxhlet extractor. The extract was concentrated using a vacuum evaporator, and the extract residue was stored at 4°C in refrigerato...
Insulin resistance is one of leading pathogenic process in diabetes mellitus type-2. It is known that high-fructose intake leads to obesity, diabetes, dyslipidemia in rodents. The aim of our study was to evaluate the effect of Blood burnet's extract on body weight, visceral fat, blood glucose, plasma insulin, lipid profiles, lipid peroxidation and enzymatic antioxidants (superoxide dismutase, catalase, glutathione reductase) in fructose-induced type-2 diabetic rats. Our results showed that in high-fructose-induced diabetic rats were observed abdominal obesity, hyperglycemia, hyperinsulinemia, increased lipid profiles and atherogenic index, decreased insulin sensitivity, activation of lipid peroxidation and reduced activities of enzymatic antioxidants. Blood burnet's extract was able to improve insulin resistance, glucose toleration, rectifies dyslipidemia and abolish the damage in antioxidant system in terms of high-fructose feeding in rats.
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