This paper presents the methodology and the results of screening for Diabetes mellitus in large population groups. The investigation consisted of two phases: the detection of glycosuria and blood sugar level 2 h after on oral glucose load; and afterwards, the perrefinance of GTT on people with blood sugar levels above the limits defined as normal for each age group.-The screening of 1314 subjects from a rural population and 7113 from an urban population, between 25 and 65 years of age indicated a prevalence of Diabetes mellitus of 1.44% and 3.7% respectively. This estimate includes diabetics already known to a special medical centre.-74.5% of the urban population and 88.7%, of the rural population were included in the screening.-Obesity was found in 51% and 69% of the newly found urban and rural diabetics, respectively. In 2.15% of the group, glycosuria was found with normal blood sugar levels during GTT, suggesting that this group should be specially recorded and subjected to periodical survey.-Screening for Diabetes mellitus solely by glycosuria testing is both inadequate and erroneous.
The ultrastructure of the liver cells during viral hepatitis is presented. The character of the noticed disturbances is variable with a rather patchy distribution, without any specificity of this disease. On the contrary remarkable and original patterns were observed at the level of the intercellular spaces; an important process of winding; presence of electronopaque grains (probably formed of biliary pigments), dilatation of the intercellular spaces between junctional complexes; joining of the cellular membranes with complete disappearance of intercellular spaces. All the disturbances in the ultrastructure of the intercellular spaces seem to help to clarify the understanding of the pathogenesis of jaundice in many cases of viral hepatitis. It may result from a sort of functional blocking of the “tight junctions” which, in its turn, may precede or be the consequence of some functional [8] perturbations, present all along the length of the intercellular spaces situated between Disse’s space and the biliary canaliculi.
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