“…13, 22J, of tissues infected with Coxsackie virus B, (12), and of L cells infected with Mengovirus (1,2). Similar changes also have been described in human viral hepatitis [33], Some of the vesicles which contain condensed cytoplasm appear to re present cisternae of endoplasmic reticulum. From this and previous studies it seems that vésiculation and vacuolization are consequences of mem brane proliferation and that this phenomenon is a host cell-virus inter action common to many viral infections, but specifically related to in fections with the picornaviruses [22], Furthermore, it is suggested that this phenomenon is an early cellular response that may precede more pro nounced degenerative changes which may be detected by light microscopy.…”