MEDICIsOURNAL 509 28 days of onset of symptoms, were reported. Residual paralysis was found in only four cases of paralytic poliomyelitis occurring between 5 and 28 days after vaccination, an incidence of 1 in four and a half million doses administered. We are indebted to the many medical officers of health, hospital clinicians, general practitioners, and virologists who have co-operated in providing information concerning their patients, and to the Ministry of Health for the statistics on the use of oral vaccine.
Studies of iodine metabolism have been carried out in 15 pregnant women, 33 cases with sporadic goitre and 11 with thyrotoxicosis. A low plasma inorganic iodine was common to the three groups. In pregnancy and sporadic goitre the thyroid clearance of iodine was elevated and the absolute iodine uptake normal. A high thyroid clearance of iodine in thyrotoxicosis was associated with a high absolute iodine uptake. The results suggest that both pregnancy and sporadic goitre are physiological responses to an iodine deficiency state while the iodine deficiency state of thyrotoxicosis is secondary to increased thyroid activity.
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