Carbenoxolone has recently been advocated (Doll et al., 1962(Doll et al., , 1965Horwich and Galloway, 1965)

MEDICIsOURNAL 509 28 days of onset of symptoms, were reported. Residual paralysis was found in only four cases of paralytic poliomyelitis occurring between 5 and 28 days after vaccination, an incidence of 1 in four and a half million doses administered. We are indebted to the many medical officers of health, hospital clinicians, general practitioners, and virologists who have co-operated in providing information concerning their patients, and to the Ministry of Health for the statistics on the use of oral vaccine.

The metabolic fate of L-histidine, summarized in Fig. 1, has been the subject of renewed interest because of the realization that some stages of its breakdown to glutamic acid are folate dependent (Bakerman, Silverman,

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