We present the design parameters, production process, and in-flight performance of the X-ray telescope (XRT) onboard Suzaku. The imaging capability is significantly improved over the ASCA XRT, which had half-power diameters of ${3\rlap {.}{}^{\mathrm {\prime }}6}$, to ${1\rlap {.}{}^{\mathrm {\prime }}8}$–${2\rlap {.}{}^{\mathrm {\prime }}3}$ for all four XRT-I modules. The optical axes are found to be distributed within a radius of ${1\rlap {.}{}^{\mathrm {\prime }}3}$, which makes the observation efficiency of all the XRTs more than 97% at the XIS-default observing position. The vignetting over the XIS field of view predicted via ray-tracing coincides with that measured for observations of the Crab Nebula to within $\sim 10\%$. Contemporaneous fits of a power law to all of the XIS spectra of the Crab Nebula taken at the two standard observing positions (XIS/HXD-default positions) gives a flux consistent with that obtained by Toor and Seward (1974, AJ, 79, 995) to within $\sim 2\%$. The pre-collimator on the top of each XRT module successfully reduces the intensity of the stray light from the $20'$ and $50'$-off directions down to the level of pre-flight expectations.

We have developed a framework for the Monte-Carlo simulation of the X-Ray Telescopes (XRT) and the X-ray Imaging Spectrometers (XIS) onboard Suzaku, mainly for the scientific analysis of spatially and spectroscopically complex celestial sources. A photon-by-photon instrumental simulator is built on the ANL platform, which has been successfully used in ASCA data analysis. The simulator has a modular structure, in which the XRT simulation is based on a ray-tracing library, while the XIS simulation utilizes a spectral "Redistribution Matrix File" (RMF), generated separately by other tools. Instrumental characteristics and calibration results, e.g., XRT geometry, reflectivity, mutual alignments, thermal shield transmission, build-up of the contamination on the XIS optical blocking filters (OBF), are incorporated as completely as possible. Most of this information is available in the form of the FITS (Flexible Image Transport System) files in the standard calibration database (CALDB). This simulator can also be utilized to generate an "Ancillary Response File" (ARF), which describes the XRT response and the amount of OBF contamination. The ARF is dependent on the spatial distribution of the celestial target and the photon accumulation region on the detector, as well as observing conditions such as the observation date and satellite attitude. We describe principles of the simulator and the ARF generator, and demonstrate their performance in comparison with in-flight data.

No abstract

High-resolution X-ray spectroscopy with Hitomi was expected to resolve the origin of the faint unidentified » E 3.5 keV emission line reported in several low-resolution studies of various massive systems, such as galaxies and clusters, including the Perseus cluster. We have analyzed the Hitomi first-light observation of the Perseus cluster. The emission line expected for Perseus based on the XMM-Newton signal from the large cluster sample under the dark matter decay scenario is too faint to be detectable in the Hitomi data. However, the previously reported 3.5 keV flux from Perseus was anomalously high compared to the sample-based prediction. We find no unidentified line at the reported high flux level. Taking into account the XMM measurement uncertainties for this region, the inconsistency with Hitomi is at a 99% significance for a broad dark matter line and at 99.7% for a narrow line from the gas. We do not find anomalously high fluxes of the nearby faint K line or the Ar satellite line that were proposed as explanations for the earlier 3.5 keV detections. We do find a hint of a broad excess near the energies of high-n transitions of S XVI (  E 3.44 keV rest-frame)-a possible signature of charge exchange in the molecular nebula and another proposed explanation for the unidentified line. While its energy is consistent with XMM pn detections, it is unlikely to explain the MOS signal. A confirmation of this interesting feature has to wait for a more sensitive observation with a future calorimeter experiment.

No abstract

PurposeAlthough several studies have demonstrated the efficacy of probiotics for preventing upper respiratory tract infections (URTIs) in at-risk populations, including children and the elderly, few studies have investigated the efficacy of probiotics in healthy adults living normal, everyday lives. Thus, we tried to evaluate the effects of Lactobacillus casei strain Shirota-fermented milk (LcS-FM) on the incidence of URTIs in healthy middle-aged office workers.MethodsIn a randomized controlled trial, 96 eligible male workers aged 30–49 years consumed LcS-FM containing 1.0 × 1011 viable LcS cells or control milk (CM) once daily for 12 weeks during the winter season. URTI episodes were evaluated by a physician via a questionnaire of URTI symptoms.ResultsThe incidence of URTIs during the intervention period was significantly lower in the LcS-FM group than in the CM group (22.4 vs. 53.2 %, P = 0.002). The time-to-event analysis showed that the LcS-FM group had a significantly higher URTI-free rate than the CM group over the test period (log-rank test: χ 2 11.25, P = 0.0008). The cumulative number of URTI episodes and cumulative days with URTI symptoms per person was lower in the LcS-FM group, and the duration per episode was shorter. Inhibition of both reductions in NK cell activity in peripheral blood mononuclear cells and increases in salivary cortisol levels was observed in the LcS-FM group.ConclusionThe results suggest that the daily intake of fermented milk with LcS may reduce the risk of URTIs in healthy middle-aged office workers, probably through modulation of the immune system.

We present the results from deep Suzaku observations of the central region of the Perseus cluster. Bulbul et al. (2014) reported the detection by XMM-Newton instruments of an unidentified X-ray emission line at an energy around 3.5 keV in spectra for the Perseus and other clusters. They argued for a possibility of the decay of sterile neutrino, a dark matter candidate. We examine Suzaku X-ray Imaging Spectrometer (XIS) spectra of the Perseus cluster for evidence in the 3.5 keV line and other possible dark matter features in the 2-6 keV energy band. In order to search for and constrain a weak line feature with the XIS, observations of the Crab Nebula are used to evaluate the system's effective area. We found no line feature at the claimed position with a systematic line flux upper limit at a half (1.5 eV in line equivalent width) of the claimed best-fit value by Bulbul et al. We discuss this inconsistency in terms of instrumental calibration errors and modeling of continuum emission. Future prospects for high-energy resolution spectroscopy with ASTRO-H are presented. 1 dark matter is still mysterious. Independent considerations consistently indicate that particles within the SU(3)× SU(2)× U(1) Standard Model of particle physics cannot comprise the main body of dark matter, suggesting a new physics beyond the Standard Model (see e.g. Feng 2010 for a recent review).Because of their extremely low interactions, some dark matter candidates can be detected only in decays or annihilation from cosmic systems with high enough numbers of particles. As one of method of indirect astronomical study, Abazajian et al. (2001) proposed a search for the X-ray decay line of a hypothetical sterile neutrino, a right-chiral counterpart of the active neutrinos. A keV-mass sterile neutrino is a warm dark matter candidate. This sterile neutrino X-ray has been examined in observations of the Milky Way, other galaxies, and galaxy clusters (e.g. Kusenko 2009, Abazajian et al. 2012, Boyarsky et al. 2012, and Horiuchi et al. 2014 ) without any clear detections. Bulbul et al. (2014; B14) found an unidentified line at around 3.5 keV in the XMM-Newton European Photon Imaging Camera (EPIC) MOS and pn detector's stacked X-ray spectra from many clusters. They reported the highest flux from the central region of the Perseus cluster. Boyarsky et al. (2014a) and Boyarsky et al. (2014b) also reported detections at the same energy in the Perseus cluster off-center, the M31 galaxy, and the Galactic center. Both groups claimed that their observed line positions and fluxes are consistent with a sterile neutrino decay signal, with cautions regarding systematic uncertainties in calibrations and contamination from atomic transitions. These detections motivated a number of theoretical studies (e.g. Nakayama et al. 2014).The possible dark matter origin suggested by B14 is intriguing. To examine the 3.5 keV line detection and origins, we analyzed deep Suzaku XIS (X-ray Imaging Spectrometer) data of the Perseus cluster center. This data set provides independent an...

Noradrenaline (NA), 3,4-dihydroxyphenylethylamine (dopamine, DA), 5-hydroxytryptamine (serotonin, 5-HT), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) were measured in 22 regions of postmortem brains from four histologically verified cases with Alzheimer-type dementia (ATD) and nine histologically normal controls. Compared with the controls, concentrations of 5-HT and 5-HIAA in the ATD brains were significantly reduced in nine regions (superior frontal gyrus, insula, cingulate gyrus, amygdala, putamen, medial and lateral segments of globus pallidus, substantia nigra, lateral nucleus of thalamus) and in eight regions (amygdala, substantia innominata, caudate, putamen, medial and lateral segments of globus pallidus, medial and lateral nuclei of thalamus), respectively. NA concentrations of the ATD brains were significantly reduced in six regions (cingulate gyrus, substantia innominata, putamen, hypothalamus, medial nucleus of thalamus, raphe area). In contrast, significant reductions of DA and HVA concentrations in the ATD brains were found only in putamen and amygdala, respectively. The 5-HIAA/5-HT ratio in the ATD brains decreased significantly in locus coeruleus, while the HVA/DA ratio increased significantly in putamen and medial segment of globus pallidus. These findings suggest that the serotonergic and noradrenergic systems are affected, while the dopaminergic system is relatively unaffected in ATD brains.