Protein-protein interactions (PPIs) play a major role in many biological processes and they represent an important class of targets for therapeutic intervention. However, targeting PPIs is challenging because often no convenient natural substrates are available as starting point for small-molecule design. Here, we explored the characteristics of protein interfaces in five non-redundant datasets of 174 protein-protein (PP) complexes, and 161 protein-ligand (PL) complexes from the ABC database, 436 PP complexes, and 196 PL complexes from the PIBASE database and a dataset of 89 PL complexes from the Timbal database. In all cases, the small molecule ligands must bind at the respective PP interface. We observed similar amino acid frequencies in all three datasets. Remarkably, also the characteristics of PP contacts and overlapping PL contacts are highly similar.

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Vitamin E is made up of two substances, tocopherols (TOCs) and tocotrienols (TCTs). These substances are present in four different subtypes namely alpha, beta, delta and gamma and these subtypes differs in their chemical structures. Vitamin E has been made known to exert anticancer effects for decades-long ago. This vitamin, which is also a well-known lipid-soluble antioxidant, has been extensively studied and its effects on cancer cells progressions are widely reported. These include its effects on the progressions of the breast, cervix, colon, liver, lung, pancreas, prostate, skin, and stomach cancers. Despite the widely available reports on vitamin E as an anticancer, the particular reports on the effects of this vitamin for reproduction in ovarian cancer are remarkably limited. Hence, this review is written to provide a summary of the reported effects from the studies published between the year 2010-2020 and the possible future research on vitamin E in ovarian cancer. This review will contribute to a more organized finding on the effects of vitamin E and ovarian cancer.

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