Hepatitis C virus (HCV) infection is a major public health problem in the Middle East. A database of 400 patients with chronic HCV in Qatar was retrospectively analysed: 242 patients underwent antiviral treatment, of whom 212 (87.6%) were naïve to treatment. The response to treatment and the predictors of response were studied. The largest group of patients were of Egyptian origin. The rate of sustained virological response (SVR) varied significantly between patients with HCV genotypes 2 or 3 (79.6%) and genotype 1 (45.6%) and 4 (the predominant genotype) (51.0%). Multivariate analysis showed that the independent predictors of SVR were age < 45 years, infection with genotypes 2 or 3, low fibrosis score on liver biopsy and naïve treatment status.
1Department of Gastroenterology, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar. 2 Department of Medical Research, Hamad Medical Corporation, Doha, Qatar (Correspondence to A. John: aniljohn44@gmail.com
Both dual and triple therapy regimes resulted in SVR rates of >95% in CHC genotype 3 who were naive non-cirrhotics. However, the SVR rates were low in treatment-experienced cirrhotics.
Background: There is increased incidence of gall stones and its variable presentations in India is a great need for a study which can provide information regarding risk factors associated with the formation of gallstones, prevalence of disease, clinical presentations and outcome of cholelithiasis. So present study done to find a relationship between body mass index (BMI) and waist to hip ratio (WHR) with cholelithiasis.Methods: The observational study was conducted in tertiary care center of SGRD Amritsar comprised of 100 patients diagnosed with pain abdomen by cholelithiasis and control comprised of 100 patients with any other cause of pain abdomen. All patients were evaluated for BMI and waist to hip ratio. BMI was calculated according to the standard formula (Quetelet’s index). The WHR was measured according to WHO protocol. Statistical tests were applied as quantitative variables were compared using unpaired t-test/Mann-Whitney test (when the data sets were not normally distributed) between the two groups. Qualitative variables were compared using chi-Square test /Fisher’s exact test.Results: A significant association of formation of gall bladder stones in female gender in comparison to their male counterpart and increased chances of formation of gall bladder stones in the patients having higher BMI and higher WHR.Conclusion: Female gender and obesity is associated with increased risk of cholelithiasis.
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