Aim: To determine the effectiveness of antiviral drugs such as sofosbuvir, daclatasvir and ribavirin in hepatitis C patients and frequency of complications associated to antiviral therapy. Study Design: Prospective study. Place and Duration: This study was conducted at the department of Gastroenterology and General Medicine AK CMH / Sheikh Khalifa bin Zaid Al Nahyan Hospital Rawalakot Azad Kashmir for one year duration from 5th July 2020 to 5th July 2021. Methodology: 150 patients of both genders presented with hepatitis C were included. Patient’s ages were ranging from 25 to 70 years. After taking informed consent from all the patients, detailed medical history including age, sex, residence and education were recorded. Quantitative PCR test was obtained before starting the antiviral therapy, kit method was used. Treatment response was examined after completion of therapy. All the statistical data was analyzed by SPSS 24.0. Results: 88 (58.67%) patients were males while 62 (41.33%) patients were females. Mean age of patients was 48.52±9.38 years. At the end of treatment, 132 (88%) patients were cured and 15 (10%) patients were not cured, 3 (2%) patients had lost to follow-up. Complications associated to therapy were noted as anemia, ascites, hepatic encephalopathy and liver cirrhosis in 40 (26.67%), 20 (13.33%), 7 (4.67%) and 6 (4%) patients respectively. Conclusion: Combination antiviral therapy with Sofosbuvir, daclatasvir and ribavirin shows better results in patients with Hepatitis C with 88% cure rate. Anemia was the most frequent complication found at end of therapy. Keywords: Hepatitis C, Sofosbuvir, Daclatasvir, Ribavirin
BACKGROUND & OBJECTIVE: Rats are commonly used in experimental studies as they have a smaller body size, they are easily available, and their genetic profiles are similar to each other as compared to humans. Kidney pathologies are the result of an imbalance between reactive oxygen species and antioxidants. Parsley aqueous extract is rich in polyphenolic contents and has nephroprotective effects. The objective of this study is to observe the effects of ramipril and parsley leaves aqueous extract in gentamicin induced nephrotoxicity. METHODOLOGY: An Experimental study consisting of 40 healthy male albino rats were randomly distributed into two categories after taking samples for baseline values of urea and creatinine: Category 1 consisted of a control group (Group 1) having 10 rats, while category 2 comprised of 30 rats, divided into three experimental groups after being given intraperitoneal injections of gentamicin (80mg/kg) per day. Group 2 was taken as disease control, while group 3 and group 4 were parsley treated and ramipril treated for 28 days, respectively. Biochemical markers (serum urea and creatinine) were done at day 35. SPSS version 22 was applied for Statistical analysis. One-way ANOVA test was used to determine any difference in mean values. Post hoc tuckeys test was applied for multiple comparisons amongst groups. p<0.05 was measured as significant. RESULTS: The treatment decreased the levels of serum urea and creatinine in nephrotoxic rats in group 3 (parsley treated group) and group 4 (ramipril treated group) in comparison to group 2. Group 3 had significantly reduced biochemical markers (p<0.05). CONCLUSION: Parsley leaves extract significantly reduced the serum urea and creatinine levels as compared to ramipril.
Drug induced liver injury has been regarded as the main cause of acute liver injury in many countries. Objectives: To evaluate the protective action of selenium against hepatotoxicity caused by methotrexate in mice. Study Design: Randomized, single blinded study. Methodology: Present study was done on 18 mice (n = 18) after taking approval from Ethical Review Committee. Administration of methotrexate induced hepatotoxicity. Selenium was administered along with methotrexate in order to evaluate the protective effects. The extent of hepatotoxicity and protective effects were analyzed by measuring levels of serum liver enzymes and histological examination of liver samples. Statistical analysis: One way ANOVA test was applied for comparison of biochemical markers between groups. Chi Square test was also applied for histopathological results. Results: In present study, results showed that significant hepatotoxicity was observed (p < 0.05) with elevated levels of serum liver enzymes with methotrexate. Selenium was found to significantly reduce the hepatotoxicity (p < 0.05). Histological examination revealed steatosis, which was found to be markedly decreased after treatment with selenium along with methotrexate. Conclusion: We concluded that selenium helped to protect against hepatotoxicity induced by methotrexate in mice. Keywords: Drug induced liver injury, Hepatotoxicity, Methotrexate and Selenium.
OBJECTIVE: To determine the factors associated with seropositivity of hepatitis B and C at Azad Jammu and Kashmir STUDY DESIGN: Case Control study. SETTING AND DURATION: Department of Gastroenterology Sheikh Khalifa Bin Zayed Al Nahyan Hospital/ AK Combined Military Hospital Rawalakot, from 1s tJanuary 2021 to 30th June 2021. METHODOLOGY: This study involved 173 patients suffering from Hepatitis B or C.144 age and gender matched healthy controls was enrolled from within the hospital. Detailed socio-demographic proforma was filled by both the cases and controls which included all the relevant factors. Pearson chi-square test was applied to look for statistically significant difference in factors associated with seropositivity of hepatitis B and C among cases and controls. RESULTS: A totalof 317 participants were included in the study. 144 were healthy controls and 173 were patients suffering from hepatitis B and C. 149 (86.1%) had hepatitis C while 24 (13.9%) had hepatitis B. Mean age of the study participants were 36.95±3.19 years. Marital status, positive family history of hepatitis B and C and history of surgery or dental procedure had statistically significant relationship with seropositivity of Hepatitis B and C (p-value<0.05) CONCLUSION: Individuals who were married or had anybody in family positive for hepatitis B and C were more at risk of having these infections. In this study dental procedures, surgeries and family history of these infections have highest incidence of risk factors associated with HCV & HBV infections
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