Defects is pivotal to endow metal oxide catalyst an efficient catalytic oxidation ability. Here, a defects engineering strategy is developed by hand-milling Co3O4 with the aid of Na at room...
For discriminating the signals of multi-targets, multiplexed
photoelectrochemical
(PEC) detection is generally accomplished by modulating the light
source or voltage, which prospect is usually limited by expensive
instrumentation, tedious operational steps, and time-consuming material
screening. To realize multiplexed determination on single photoelectric
interface using the routine technique, a non-instrument-assisted strategy
for signal discrimination needs to be explored. Herein, we propose
an exonuclease III-mediated multiple PEC signals resolution strategy
and construct a self-cleaning recyclable multiplexed PEC sensor using
a porphyrin-bipyridine-based covalent organic framework (Por-Bpy COF)
photocathode. Specifically, following the dual-target recognition
event, exonuclease III cleaves the DNA strand attached to the magnetic
bead so that the two signal labels can be separated. Once the signal
label binds to the DNA on the electrode surface (E-DNA), exonuclease
III turns to excise the DNA strand of the signal label and consequently
the E-DNA can repeatedly bind different signal labels. As a result,
distinguishable photocurrent signals of different targets can be generated
on a single photoelectric interface. The feasibility of this multiplexed
sensor is verified by detecting two coexisting mycotoxins aflatoxin
B1 and zearalenone. On account of eliminating the instrumentation
constraints and simplifying the experimental procedures, the proposed
sensing strategy may provide a brand-new idea for the exploration
of portable multiplexed PEC sensing devices.
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