No abstract

Captopril is an antihypertensive agent that inhibits the angiotensin‐converting enzyme of the renin–angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril.© 2001 Society of Chemical Industry

2002 carboxylic amides carboxylic amides (benzene compounds) Q 0490 -061Resolution of (RS)-Proglumide Using Lipase from Candida cylindraceae.--(MURALIDHAR, R. V.; CHIRUMAMILLA, R. R.; RAMACHANDRAN, V. N.; MARCHANT, R.; NIGAM, P.; Bioorg. Med.

No abstract

Captopril is an antihypertensive agent that inhibits the angiotensin-converting enzyme of the renin±angiotensin system. Chiral intermediates are used in the synthesis of the drug. These intermediates are obtained by resolution of racemic compounds or by chemical, biocatalytic methods and or by asymmetric synthesis by biocatalytic process. This article reviews the various chemical and biochemical processes involved in the synthesis of the chiral drug, including the pharmacological action of captopril.