The synthesis of nine original morpholine derivatives, i.e. 2‐aryl‐4‐(3‐arylpropyl)morpholines, is described. The structure of all synthesised derivatives was proved by IR and 1H‐NMR, and some of them by 13C‐NMR. Acute toxicity studies of the compounds were performed on mice. A comparative pharmacological study of the in vivo effects on the central nervous system was undertaken using the screening tests: hexobarbital induced sleeping time; locomotor activity; and behaviour despair (for antidepressive activity). The most active compound 4‐(2‐benzoylethyl)‐2‐phenyl‐3‐methyl) morpholine 4e was studied for MAO‐A and MAO‐B inhibition in vitro in rat brain mitochondria preparations.
Two new Pd(II) complexes with 3-amino-5-methyl-5-(4-pyridyl)-hydantoin (AMPH) were synthesized: cis-[Pd(AMPH) 2 Cl 2 ]Á2H 2 O and cis-[Pd(AMPH) 2 Br 2 ]ÁH 2 O. The complexes were characterized by physico-chemical and spectroscopic methods. The determination of crystal water content in the complexes was defined by Karl Fisher titration. The cytotoxic effects of these complexes were examined on a panel of human tumor cell lines. Qualitative antimicrobial assays on three pathogenic microorganisms of the new complexes, their analogues with 5-methyl-5-(4-pyridyl)-hydantoin(MPH) and their platinum analogues were made. Cis-[Pd(mpyh) 2 Br 2 ]ÁH 2 O showed significant activity against C. albicans.
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