The synthesis of nine original morpholine derivatives, i.e. 2‐aryl‐4‐(3‐arylpropyl)morpholines, is described. The structure of all synthesised derivatives was proved by IR and 1H‐NMR, and some of them by 13C‐NMR. Acute toxicity studies of the compounds were performed on mice. A comparative pharmacological study of the in vivo effects on the central nervous system was undertaken using the screening tests: hexobarbital induced sleeping time; locomotor activity; and behaviour despair (for antidepressive activity). The most active compound 4‐(2‐benzoylethyl)‐2‐phenyl‐3‐methyl) morpholine 4e was studied for MAO‐A and MAO‐B inhibition in vitro in rat brain mitochondria preparations.
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