Synthesis of palladium(II) complexes with 3-amino-5-methyl-5-(4-pyridyl)-hydantoin: cytotoxic and antimicrobial investigations and comparison with their platinum analogues

Abstract

Two new Pd(II) complexes with 3-amino-5-methyl-5-(4-pyridyl)-hydantoin (AMPH) were synthesized: cis-[Pd(AMPH) 2 Cl 2 ]Á2H 2 O and cis-[Pd(AMPH) 2 Br 2 ]ÁH 2 O. The complexes were characterized by physico-chemical and spectroscopic methods. The determination of crystal water content in the complexes was defined by Karl Fisher titration. The cytotoxic effects of these complexes were examined on a panel of human tumor cell lines. Qualitative antimicrobial assays on three pathogenic microorganisms of the new complexes, their analogues with 5-methyl-5-(4-pyridyl)-hydantoin(MPH) and their platinum analogues were made. Cis-[Pd(mpyh) 2 Br 2 ]ÁH 2 O showed significant activity against C. albicans.

Platinum Complexes with 5‐Methyl‐5(4‐pyridyl)hydantoin and Its 3‐Methyl Derivatives: Synthesis and Cytotoxic Activity – Quantitative Structure‐Activity Relationships

“…1. The structures are confirmed by the IR and NMR spectra of the new compounds and are in accordance with previously synthesized by us complexes [4][5][6][7].…”

“…The newly four synthesized and tested complexes were added to 12 previously evaluated compounds [4][5][6][7] and a set of 16 similar compounds was compiled. Free-Wilson model was derived by PLS and the contribution of each substituent was assessed quantitatively.…”

“…Data from the elemental analysis, IR, NMR spectral analysis and molar conductivity demonstrated the coordination mode of the ligands with metal ions. In all complexes the ligand was coordinated monodentatelly with M 2þ and Pt 4þ via N-atom from the pyridine ring [4][5][6][7]. The present study represents the synthesis and physicochemical evaluation of four new Pt(II) and Pt(IV) complexes with 3,5-dimethyl-5-(4-pyridyl)hydantoin (L) and 5-methyl-5-(4-pyridyl)hydantoin (L 1 ).…”

Platinum(IV) Complexes with Some Derivatives of 5-Methyl-5-(4-pyridyl)Hydantoin. Synthesis, Study and Comparative Pharmacological Investigation

“…The newly synthesized Pt(IV) complexes ( 4 ), ( 5 ) and ( 6 ) were characterized by elemental analysis, IR, 1 H, 13 C NMR spectra. The carbon, nitrogen and hydrogen contents of the compounds were determined by elemental analysis.…”

Carbohydrate triazole tethered 2-pyridyl-benzimidazole ligands: Synthesis of their palladium (II) complexes and antimicrobial activities

“…However, as a consequence of the rapid hydrolysis in aqueous solutions and lower bioactivity of palladium complexes, an appropriate ligand system which can sustain the biological environment is required [20]. Several palladium complexes with different nitrogen ligands have been designed for biological applications [21][22][23][24][25][26][27][28][29][30][31][32][33].…”