Specific immunotherapy was observed retrospectively to reduce new sensitizations in monosensitized subjects suffering from respiratory allergic diseases.
Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH.
Aging is associated to a progressive establishing of a chronic
inflammatory state linked to a continuous long exposure to
antigens. Since IL-15 stimulates the proliferation of memory T
cells and the immunosenescence is characterized by accumulation
of memory T cells and exhaustion of naive T cells, we analyzed
IL-15 levels in sera from 30 ultralongeval subjects with respect to
those from young and old adults. IL-15 levels were assayed by
immunoenzymatic methods. Ultralongeval subjects displayed
significantly higher IL-15 levels with respect to both young and
old controls. No statistical difference was found between old and
young controls. These findings may explain, at least in part, the
characteristic increase of memory cells in immunosenescence and
the capacity of the immune system of centenarians to defend
itself from infections through immune-inflammatory responses.
IL-18 and sICAM-1 levels in the patients were significantly higher than in the HDs (385.94 +/- 193.89 vs. 227.38 +/- 92.76 pg/mL, P = 0.005 and 445.00 +/- 152.67 vs. 317.88 +/- 107.20 ng/mL, P = 0.02, respectively). On the contrary, no significant difference was found between serum sCD30 levels of patients in respect to those of HDs. A significant correlation was found between serum IL-18 and PASI (Rho = 0.695, P = 0.0071), serum IL-18 and sICAM-1 (Rho = 0.543, P = 0.0356) and between sICAM-1 and PASI (Rho = 0.659, P = 0.0107).
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