Malondialdehyde in benign prostate hypertrophy: a useful marker?

Merendino, Rosaria Alba; Salvo, Francesco; Saija, Antonella; Pasquale, Giuseppe Di; Tomaino, Antonio; Minciullo, Paola Lucia; Fraccica, Giuseppe; Gangemi, Sebastiano

doi:10.1080/0962935031000097745

Cited by 55 publications

(54 citation statements)

References 5 publications

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“…Plasma MDA, a key marker of lipid peroxidation, and the most abundant aldehyde generated by the attack of free radicals on polyunsaturated fatty acids of cell membranes, is a non-invasive biomarker of OS in BPH [41,42]. Reductions of plasma MDA with D-004 (32.5%) and SP (28.2%) achieved the efficacy criterion (20.0% decrease versus baseline).…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of Roystonea Regia (D-004) and Saw Palmetto Lipid Extracts On Blood Oxidative Variables in Men with Benign Prostate Hyperplasia (BPH)

Guzman¹

2013

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Section: Discussionmentioning

confidence: 99%

Comparative Effects of Roystonea Regia (D-004) and Saw Palmetto Lipid Extracts On Blood Oxidative Variables in Men with Benign Prostate Hyperplasia (BPH)

Guzman¹

2013

iosrphr

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“…[13][14][15][16] Pasquale et al 17 demonstrated an association between lipid peroxides and PSA. Although oxidative stress and increase in sialoglycoprotein level and/or sialic acid content are reported in Ca prostate separately; however there are no reports correlating oxidative stress with sialylation parameters in both BPH and Ca prostate.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of serum protein-bound sialic acid in benign and malignant prostatic growth: possible role of oxidative stress in sialic acid homeostasis

Goswami

Nandeesha

Koner

et al. 2007

Prostate Cancer Prostatic Dis

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Benign and malignant prostatic growths are associated with an increase in sialoconjugates (e.g. prostate-specific antigen (PSA)) in blood. Oxidative stress plays a crucial role in pathogenesis of various malignancies. The objective of this study was to evaluate oxidative stress parameters and protein-bound sialic acid level in sera of prostatic tumor cases and to asses for any association between them. Sera samples were collected and estimated for carbonylation of proteins, lipid peroxidation products, PSA and protein-bound sialic acid from 10 patients in each group with prostatic carcinoma (Ca prostate) and benign prostatic hyperplasia (BPH) along with 10 healthy male subjects of similar age group as control. In carcinoma prostate cases, lipid peroxides, protein carbonyls, protein-bound sialic acid and PSA were significantly increased compared to BPH and controls. There was significant association between oxidative stress parameters (lipid peroxide and protein carbonyl) and sialoconjugates (PSA and protein-bound sialic acid). In BPH cases, serum lipid peroxides and protein-bound sialic acid were significantly higher in comparison to controls and protein carbonyls were correlated with protein-bound sialic acid. ROC curve for sialic acid showed that it can be used as a marker to differentiate carcinoma prostate from benign growth of prostate at a cutoff level of 11.38 lg/mg protein with a sensitivity of 100% and specificity of 80%. We conclude that oxidative stress might be associated with the degree of sialylation of protein and graded changes in these parameters possibly unveil the pathogenic demarcation from benign to malignant condition of prostate.

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“…Circulating MDA levels were found to be significantly higher in BPH patients than in healthy donors [17,[23][24][25] and strongly correlated with prostate-specific antigen levels [23] . However, other works found circulating MDA levels in BPH patients similar to those in controls [26] .…”

Section: Role Of Oxidant Production ( Table 1 )mentioning

confidence: 99%

Oxidative Stress in Benign Prostatic Hyperplasia: A Systematic Review

Minciullo

Inferrera²,

Navarra³

et al. 2014

Urol Int

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cepted that free radicals play a role in carcinogenesis and that BPH should be considered a premalignant condition which may evolve into prostate cancer. High OS parameters and low antioxidant activity are more prominent in prostate cancer patients compared with BPH and controls. Conclusions: Further studies are needed to clarify the potential role of antioxidants in BPH also in view of preventing the progression to prostate cancer. IntroductionBenign prostatic hyperplasia (BPH) is a prevalent and chronic progressive disease that may be correctly defined as prostate gland enlargement secondary to hyperproliferation of stromal and glandular cells, with predominance of mesenchymal cells [1] . It is an extremely common disease of ageing men and carries a distressingly high morbidity because of its irritative and obstructive symptoms. The etiology and pathogenesis of BPH are not well understood [2] . Key WordsAntioxidants · Benign prostatic hyperplasia · Oxidative stress Abstract Background: Several parameters including inflammatory mediators, hormones, dietary factors, inflammatory genes, and oxidative stress (OS) have been considered to play a role in the development of benign prostatic hyperplasia (BPH). Prostate tissue damage and OS may lead to compensatory cellular proliferation with resulting hyperplastic growth. Methods: We searched MEDLINE for articles in English published up to March 2014 using the key words 'oxidative stress', 'antioxidants' and 'benign prostatic hyperplasia'. Results: Prostatic inflammation can cause the generation of free radicals. The extent of oxidative damage can be exacerbated by a decreased efficiency of antioxidant defense mechanisms. The balance between OS and the antioxidant component also has a role in developing prostate disease. Several works show the role of oxidant products and of depletion of antioxidant substances in BPH patients. It is ac-

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Malondialdehyde in benign prostate hypertrophy: a useful marker?

Cited by 55 publications

References 5 publications

Comparative Effects of Roystonea Regia (D-004) and Saw Palmetto Lipid Extracts On Blood Oxidative Variables in Men with Benign Prostate Hyperplasia (BPH)

Comparative Effects of Roystonea Regia (D-004) and Saw Palmetto Lipid Extracts On Blood Oxidative Variables in Men with Benign Prostate Hyperplasia (BPH)

A comparative study of serum protein-bound sialic acid in benign and malignant prostatic growth: possible role of oxidative stress in sialic acid homeostasis

Oxidative Stress in Benign Prostatic Hyperplasia: A Systematic Review

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