Incidence of sensitivity to Anisakis simplex in a risk population of fishermen/fishmongers

Purello-D'Ambrosio, F; Pastorello, Elide A.; Gangemi, Sebastiano; Lombardo, Giuseppe; Ricciardi, L; Fogliani, Olga; Merendino, Rosaria Alba

doi:10.1016/s1081-1206(10)62278-8

Cited by 48 publications

(35 citation statements)

References 21 publications

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“…21,2008 ANISAKIS SIMPLEX PATHOGENESIS 363 appeared from the central region of Spain but were there associated with gastrointestinal anisakidosis and with raw anchovies in vinegar (69). Moreover, a significant number of fishmongers and fishermen in Italy and African fish-processing workers, as well as 13% of healthy blood donors, are sensitized to this parasite (82,201,221). It should be borne in mind, however, that specific immunoglobulin E (IgE) detection by ImmunoCAP assay can overestimate the number of sensitized subjects (165,167), so the above estimates may be exaggerated.…”

Section: Allergic Symptomsmentioning

confidence: 99%

“…In other countries, where Pseudoterranova is more frequent (such as the United States), perhaps this parasite's allergens should be tested for when testing for fish allergy. As far as the occupational aspect is concerned, there are reports from the Basque Country (27), other regions of Spain (12,17,220), Italy (221), and South Africa (201).…”

Section: Human Susceptibility Factorsmentioning

confidence: 99%

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Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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SUMMARY Infection of humans with the nematode worm parasite Anisakis simplex was first described in the 1960s in association with the consumption of raw or undercooked fish. During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated with food preparations previously considered safe. Not only may allergic symptoms arise from infection by the parasites (“gastroallergic anisakiasis”), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes. Over the last 20 years, several studies have concentrated on A. simplex antigen characterization and innate as well as adaptive immune response to this parasite. Molecular characterization of Anisakis allergens and isolation of their encoding cDNAs is now an active field of research that should provide improved diagnostic tools in addition to tools with which to enhance our understanding of pathogenesis and controversial aspects of A. simplex allergy. We also discuss the potential relevance of parasite products such as allergens, proteinases, and proteinase inhibitors and the activation of basophils, eosinophils, and mast cells in the induction of A. simplex-related immune hypersensitivity states induced by exposure to the parasite, dead or alive.

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Section: Allergic Symptomsmentioning

confidence: 99%

Section: Human Susceptibility Factorsmentioning

confidence: 99%

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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“…The other clinical form is triggered by repeated consumption of thermally processed seafood that contains the whole nematode or its molecular traces, inducing hypersensitivity in the consumer and an array of allergic symptoms: acute urticaria and angioedema, bronchospasm, fatal respiratory arrest, and anaphylaxis (16,17). Rheumatologic diseases and disorders like asthma, gingivostomatitis, conjunctivitis, and contact dermatitis have also been related to occupational exposure to allergens in fishmongers, fishermen, or employees of the fish-processing industry (18).…”

mentioning

confidence: 99%

Ecology and Genetic Structure of Zoonotic Anisakis spp. from Adriatic Commercial Fish Species

Mladineo

Poljak

2014

Appl Environ Microbiol

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Consumption of raw or thermally inadequately treated fishery products represents a public health risk, with the possibility of propagation of live Anisakis larvae, the causative agent of the zoonotic disease anisakidosis, or anisakiasis. We investigated the population dynamics of Anisakis spp. in commercially important fish-anchovies (Engraulis encrasicolus), sardines (Sardina pilchardus), European hake (Merluccius merluccius), whiting (Merlangius merlangus), chub mackerel (Scomber japonicus), and Atlantic bluefin tuna (Thunnus thynnus)-captured in the main Adriatic Sea fishing ground. We observed a significant difference in the numbers of parasite larvae (1 to 32) in individual hosts and between species, with most fish showing high or very high Anisakis population indices. Phylogenetic analysis confirmed that commercial fish in the Adriatic Sea are parasitized by Anisakis pegreffii (95.95%) and Anisakis simplex sensu stricto (4.05%). The genetic structure of A. pegreffii in demersal, pelagic, and top predator hosts was unstructured, and the highest frequency of haplotype sharing (n ‫؍‬ 10) was between demersal and pelagic fish.

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“…This is an important clinical question in view of the fact that several case and prevalence studies, including ours, indicate that sensitization by inhalation of Anisakis proteins might be an important cause of work-related allergies (1,3,7,37,39,40). Aerosolized food allergens cause as much as 10% of asthma in the occupational environment (41), and Anisakis allergens aerosolized during fish cleaning, cooking, or fish meal production may therefore pose a risk for workers.…”

mentioning

confidence: 88%

Anisakis pegreffii-Induced Airway Hyperresponsiveness Is Mediated by Gamma Interferon in the Absence of Interleukin-4 Receptor Alpha Responsiveness

et al. 2010

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Incidence of sensitivity to Anisakis simplex in a risk population of fishermen/fishmongers

Cited by 48 publications

References 21 publications

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

Ecology and Genetic Structure of Zoonotic Anisakis spp. from Adriatic Commercial Fish Species

Anisakis pegreffii-Induced Airway Hyperresponsiveness Is Mediated by Gamma Interferon in the Absence of Interleukin-4 Receptor Alpha Responsiveness

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