their ability to induce ataxia, to decrease locomotor activity, and to afford protection against electroshockand strychnine-induced convulsions in mice. In general, the compounds described herein failed to afford protection at an acceptable dose (<50 mg/kg) against convulsions induced by either method. However, many compounds induced ataxia, as judged by impairment of ability to traverse a suspended rod, and decreased motor activity. The data for the more interesting compounds are summarized in Table I; comparable data for Mannich base 1 are included.
This review surveys analytical methodology and subjects related to pharmaceutical analysis that appeared in Chemical Abstracts (CA) or Analytical Abstracts (AA) during the period between June 1974 and June 1976. The authors were selective and attempted to cite only those references that appeared to be significant and appeared in easily accessible journals. It is not as encompassing as the previous Pharmaceutical Review in 1975.The bibliography is divided into nine sections with separate numbering of each. The sections are Alkaloids (A), Antibiotics (B), Inorganic and Metal Containing Compounds (I), Sulfur Containing Compounds (S), Nitrogen and Oxygen Containing Compounds (N), Steroids (R), Vitamins (V), Formulations and Mixture (F), and New Techniques (T).
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