Monolithic microfluidic reactors for the safe, expedient, and
continuous synthesis of products involving unstable intermediates were fabricated and assessed. The formation of diazonium
salts in anhydrous conditions and their subsequent in situ
chlorination within microfluidic channels under hydrodynamic
pumping regimes is presented. Significant enhancements in yield
were observed due to enhanced heat and mass transfer in
microfluidic systems. Analysis performed using off-line GC and
GC−MS was compared with on-line, on-chip Raman spectroscopy for the direct determination of analytes.
Monolithic nanoreactors for the safe and expedient continuous synthesis of products requiring unstable intermediates were fabricated and tested by the synthesis of azo dyes under hydrodynamic pumping regimes.
Purpose: Induction of apoptosis in tumors is considered a desired goal of anticancer therapy. We investigated whether the dynamic temporal and spatial evolution of apoptosis in response to cytotoxic and mechanism-based therapeutics could be detected noninvasively by the caspase-3 radiotracer [18 F]ICMT-11and positron emission tomography (PET).
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