Microfluidic routes to the controlled production of nanoparticlesElectronic supplementary information ESI available: image of the central portion of the micromixer chip. See http://www.rsc.org/suppdata/cc/b2/b202998g/

Edel, Joshua B.; Fortt, Robin; deMello, John C.; deMello, Andrew J.

doi:10.1039/b202998g

Cited by 268 publications

(122 citation statements)

References 11 publications

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“…[167] In contrast with conventional batch systems, the use of MF to study and optimize the fabrication of a wide range of nanoparticles is attracting more and more attention [167] and their use for chemical synthesis gained a quick development with notable contributions from researchers at GlaxoSmithKline (UK), [168] Massachusetts Institute of Technology (USA), [169] the Institut für Mikrotechnik Mainz (Germany) [170] and Imperial College London (UK). [171] Since the first use of MF to prepare Cd nanoparticles on a lab-on-a-chip device, [172] advancement in the area of chemical synthesis of nanomaterials has been accelerated over the past decade. [39] Since then, various nanoparticles such as metal, [173] metal oxide, [174] semiconductors, [175] organic, [176] inorganic, etc., have been synthesized in MF systems, for example CdSe, Cds, Ti 2 O, boehmite, Au, Co, Ag, Pd, Cu, BaSO 4 , and CdSe − ZnS core-shell nanoparticles.…”

Section: Microfluidic Synthesis Of Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Microfluidic Synthesis Of Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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“…[46,76] Über die Mikrofluidiksynthese von CdS-Nanopartikeln nach Zusammenmischen von CdNO 3 und Na 2 S (in Gegenwart eines Natriumpolyphosphat-Stabilisators) in einem laminaren Mikromischer [77] berichteten zuerst 2002 Edel et al in der Gruppe um deMello. [71] Durch Verlängerung der Verweilzeit der Reagentien erreichte man eine breite Verteilung der Kristallitgrößen mit einer besseren Monodispersität als bei der Volumensynthese. Da laminare Reaktoren durch Taylor-Dispersion und Verstopfen beeinträchtigt sind, isolierten Shestopalov et al [78] die Reaktion innerhalb wässriger Tröpfchen, die von einem wasserunlöslichen Fluorkohlenstofföl umgeben und transportiert wurden (Abbildung 5).…”

Section: Synthese Von Halbleiternunclassified

Mikrofluidik in der anorganischen Chemie

2010

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In den letzten Jahren hat die Mikrofluidik in der Chemie stark an Bedeutung gewonnen. Miniaturisierte chemische Vorrichtungen ermöglichen einen kontrollierten Flüssigkeitstransport und schnelle chemische Reaktionen und sind darüber hinaus Kosten sparend, wenn man sie mit konventionellen Reaktoren vergleicht. Sowohl in der (Bio‐)Analytik als auch in der organischen Synthese werden diese Vorteile bereits ausgiebig genutzt, weniger hingegen in der anorganische Chemie und den Materialwissenschaften. Dennoch wird diese Thematik auch in der Anorganik bei der Entwicklung von Mikroreaktoren für die Trennung und selektive Extraktion von Metallionen gestreift. Bei Funktionsmaterialien wird die Mikrofluidik hauptsächlich für Verbesserungen in der Synthese von Nanopartikeln (besonders von Metall‐, Metalloxid‐ und Halbleiternanopartikeln) eingesetzt. Mikrofluidiktechniken können auch für die Entwicklung von komplizierteren anorganischen (Hybrid‐)Materialien genutzt werden.

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“…The application of microfluidic devices to cadmium sulfide particle synthesis was reported by several research groups [1,2]. The production of cadmium selenide nanocrystals was presented by Chan et al [3].…”

Section: Introductionmentioning

confidence: 98%

Droplet Formation by the Collision of Two Aqueous Solutions in a Microchannel and Application to Particle Synthesis

et al. 2007

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A new microreactor suitable for reaction crystallization was developed. In order to prevent particles from depositing on the channel wall, the reactants were injected into a stream of immiscible fluids, so that droplets consisting of the reactants were formed. This microreactor can be used to synthesize particles without fouling. The microreactor was applied to calcium carbonate precipitation and silver particle synthesis. Fouling did not occur, even when calcium carbonate precipitation was undertaken continuously for 9 h. In the silver particle synthesis, the particles obtained showed a narrower size distribution and a smaller degree of agglomeration. The fluid dynamics in the microreactor were also investigated using a computational fluid dynamics simulation. The mixing behavior in the droplets was affected by the flow conditions of the reactants.

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Microfluidic routes to the controlled production of nanoparticlesElectronic supplementary information ESI available: image of the central portion of the micromixer chip. See http://www.rsc.org/suppdata/cc/b2/b202998g/

Abstract: A microfluidic procedure for the controlled production of cadmium sulfide nanoparticles is described.

Cited by 268 publications

References 11 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mikrofluidik in der anorganischen Chemie

Droplet Formation by the Collision of Two Aqueous Solutions in a Microchannel and Application to Particle Synthesis

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