These results are consistent with deficits in hippocampal function and structure in abuse-related PTSD.

Background-Patients with posttraumatic stress disorder (PTSD) show a reliable increase in PTSD symptoms and physiological reactivity following exposure to traumatic pictures and sounds. In this study neural correlates of exposure to traumatic pictures and sounds were measured in PTSD.

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These findings are consistent with our previous hypothesis of enhanced norepinephrine release in the brain with yohimbine in patients with PTSD.

Specific brain regions, including the middle frontal gyrus, thalamus, and orbitofrontal cortex, may mediate the symptoms of patients with major depression.

Depression is an important independent contributor to medical and psychosocial morbidity up to 6 months after CABG. These findings warrant replication with larger and more diverse populations.

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