Intact systolic left ventricular function in clinical congestive heart failure

Soufer, Robert; Wohlgelernter, Daniel; Vita, Néstor A.; Amuchestegui, Marcos; Sostman, Henry Dirk; Berger, Harvey J.; Zaret, Barry L.

doi:10.1016/0002-9149(85)90741-6

Cited by 484 publications

(110 citation statements)

References 30 publications

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“…CHF is a very common clinical disorder; with noninvasive cardiac testing revealing that as many as one-third of these patients have normal left ventricular systolic function, implicating diastolic dysfunction as the primary cause of their symptoms. 27,28 Because the present study also involved many CHF patients with normal systolic function, so LVEF and NE tended to be improved after therapy and they might not be significant. On the other hand, BNP is a neurohormone secreted mainly in the cardiac ventricles in response to volume expansion and pressure overload.…”

Section: Comparison With Other Risk Predictors To Identify High-risk mentioning

confidence: 92%

Very Low Frequency Power of Heart Rate Variability is a Powerful Predictor of Clinical Prognosis in Patients With Congestive Heart Failure

Hadase

Azuma

Zen

et al. 2004

Circ J

171

112

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Section: Comparison With Other Risk Predictors To Identify High-risk mentioning

confidence: 92%

Very Low Frequency Power of Heart Rate Variability is a Powerful Predictor of Clinical Prognosis in Patients With Congestive Heart Failure

Hadase

Azuma

Zen

et al. 2004

Circ J

171

112

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“…LV diastolic dysfunction -namely impaired myocardial relaxation and increased stiffness -is the hallmark of HFpEF [34][35][36][37][38][39][40][41], however, it is not the only underlying abnormality. Other factors -both cardiac and extracardiac -including increased arterial stiffness, altered ventricular-arterial coupling [42,43], endothelial dysfunction, reduced vasodilator reserve [44,45] and chronotropic incompetence [46,47] have been recently implicated in the pathophysiology of this complex syndrome.…”

Section: Pathophysiologymentioning

confidence: 99%

Heart Failure with Preserved Ejection Fraction

Čulić

2017

N Engl J Med

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Heart failure with preserved ejection fraction (HFpEF) has recently emerged as a major cause of cardiovascular morbidity and mortality. Contrary to initial beliefs, HFpEF is now known to be as common as heart failure with reduced ejection fraction (HFrEF) and carries an unacceptably high mortality rate. With a prevalence that has been steadily rising over the past two decades, it is very likely that HFpEF will represent the dominant heart failure phenotype over the coming few years. The scarcity of trials in this semi-discrete form of heart failure and lack of unified enrolment criteria in the studies conducted to date might have contributed to the current absence of specific therapies. Understanding the epidemiological, pathophysiological and molecular differences (and similarities) between these two forms of heart failure is cornerstone to the development of targeted therapies. Carefully designed studies that adhere to unified diagnostic criteria with the recruitment of appropriate controls and adoption of practical end-points are urgently needed to help identify effective treatment strategies.

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“…Lack of two-dimensional measurements of left ventricular function is a limitation, but as grossly asymmetric contractions were rare the M-mode data should represent useful indices of left ventricular function. In earlier hospital-based studies, the prevalence of normal systolic function in CHF varied from 41 to 47 % in the elderly [7,8,23,24] and between 30 and 40 % in younger patients [25][26][27]. Recently, preliminary data were reported from the Framingham Heart Study indicating a prevalence of 52 % for echocardiographically normal left ventricular systolic function in individuals with CHF aged, on average, 73 years [28].…”

Section: Left Ventricular Function In Chfmentioning

confidence: 99%

Congestive heart failure in old age: prevalence, mechanisms and 4‐year prognosis in the Helsinki Ageing Study

Kupari

Lindroos

Iivanainen

et al. 1997

Journal of Internal Medicine

214

103

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Abstract. Kupari M, Lindroos M, Iivanainen AM, Heikkila$ J, Tilvis R. (Helsinki University Central Hospital, Helsinki, Finland). Congestive heart failure in old age : prevalence, mechanisms and 4-year prognosis in the Helsinki Ageing Study. J Int Med 1997 ; 241 : 387-94.Objective. To examine the prevalence, underlying diseases, abnormalities of left ventricular function and prognosis in congestive heart failure (CHF) of old age. Design. A population-based clinical and echocardiographic study with a 4-year mortality followup. Setting. University hospital. 1904, 1909 and 1914 (367 women). Main outcome measures. Presence of CHF by clinical and chest radiograph criteria ; left ventricular size and systolic function by echocardiography ; grade of aortic and mitral valve lesions by Doppler echocardiography ; 4-year total and cardiovascular mortality. Results. Forty-one of 501 participants (8.2 %) had CHF. Ischaemic heart disease (54 %), hypertension (54 %) and moderate-to-severe mitral or aortic valve Subjects. Five hundred and one individuals born in

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Intact systolic left ventricular function in clinical congestive heart failure

Cited by 484 publications

References 30 publications

Very Low Frequency Power of Heart Rate Variability is a Powerful Predictor of Clinical Prognosis in Patients With Congestive Heart Failure

Very Low Frequency Power of Heart Rate Variability is a Powerful Predictor of Clinical Prognosis in Patients With Congestive Heart Failure

Heart Failure with Preserved Ejection Fraction

Congestive heart failure in old age: prevalence, mechanisms and 4‐year prognosis in the Helsinki Ageing Study

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