The antagonist activity of the title compound 2 and some open chain and cyclic analogs on glycerol release from adipose tissue and incorporation of mevalonate-#-1"^into nonsaponifiable products of rat liver homogenate in vitro is discussed. Greater structural specificity was observed for the inhibition of cholesterol biosynthesis than for inhibition of lipolysis. A proposed mechanism for the antilipolytic effect of 2 is described.
Die aus 3‐Acetoxy‐chinuclidin (II) und Alkylbromiden (I) bzw. α‐Bromketonen (VI) erhaltenen quaternären Chinuclidiniumsalze (III) bzw. (VII) liefern bei der Hydrierung in Gegenwart von Palladium/Aktivkohle kein hydriertes Ammoniumsalz, sondern die Kohlenwasserstoffe (IV) bzw. die Alkohole (VIII) und 3‐Acetoxy‐chinuclidin‐hydrobromid (V).
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