Hypocholesterolemic agents. Compounds related to ethyl .alpha.-(4-chlorophenoxy)-.alpha.-methylpropionate

Synthesis and Structure−Activity Relationships of Chiral Allosteric Modifiers of Hemoglobin

“…The latter method employed condensation of the corresponding amidophenol with an R-bromo ester in the presence of base followed by base hydrolysis of the ester to give the desired R-aryloxy acid product. 22 Resolution and Stereochemistry. Crystallization from ethanol of (()-30 cinchonidine salt, the monomethyl analogue of RSR13, gave (-)-30.…”

Effects of Substituent and Temperature on Enantioselectivity for Lipase-Catalyzed Esterification of 2-(4-Substituted Phenoxy) Propionic Acids in Organic Solvents

“…Isopropyl ether and n-butyl alcohol (analytical grade) were purchased from Wako Pure Chemical Industries, Ltd. (Japan) and used without further purification. Racemic 2-(4-substituted phenoxy)propionic acids 1-7 were prepared by the reaction of 4-substituted phenols and ethyl 2-bromopropionate (Tokyo Kasei Kogyo Co., Ltd., Japan), according to the known method (13), followed by the hydrolysis of the ester.…”

Structural aspects of phenoxyalkanoic acids. The structures of phenoxyacetic acid, (+–)-2-phenoxypropionic acid, (+–)-2-(4-chlorophenoxy)propionic acid, 2-methyl-2-phenoxypropionic acid and 2-(4-chlorophenoxy)-2-methylpropionic acid

“…The basic "aluminium salt of 2-methyl-2-phenoxypropionic acid, medically known as Atherolip, has been used to treat atherosclerosis (Merck Index, 1968). The parent compound, a-phenoxyisobutyric acid, is also reported to have comparable blood-cholesterol-lowering properties (Witiak, Chun-Lun Ho, Hackney & Connor, 1968).…”