Non-communicable diseases are the most common diseases suffered by the geriatric group. Hypertension is included in the top ten diseases in geriatrics. Adherence is a major determinant of the effectiveness of treatment diseases with long term therapy such as hypertension. This study aims to analyze the relationship between adherence and outcome of antihypertensive therapy in geriatrics at the Tresna Werdha Nirwana Puri Social Center, Samarinda. The study was conducted in June -July 2020 with a cross sectional research design. Measuring adherence using a questionnaire medication adherence rating scale (MARS). The outcome therapy was stated to be achieved if the blood pressure was < 150/90 mmHg. The results showed that 62,5% of respondents had low adherence to the therapy. There was no significant relationship between adherence and therapeutic outcome (p value 0,325), however, respondents who had high adherence reached more of their therapeutic outcome targets (55,6%) than those who did not.
LATAR BELAKANG : Efek samping obat antituberkulosis yaitu toksik terhadap sel hati, disebut hepatotoksik, perlu menjadi perhatian dalam pengobatan tuberkulosis. Adanya efek samping yang tidak diinginkan ini menjadi tantangan dalam pengobatan karena dapat menyebabkan penghentian terapi atau perubahan rejimen. Koinfeksi dengan infeksi HIV juga diduga dapat meningkatkan potensi hepatotoksisitas obat antituberkulosis. TUJUAN : Penelitian ini bertujuan untuk mengetahui kejadian hepatotoksisitas obat anti tuberkulosis pada pasien tuberkulosis dan koinfeksi tuberkulosis-HIV. METODE : Penelitian ini merupakan penelitian observasional dengan desain cross sectional, yang dilakukan di salah satu rumah sakit Kota Samarinda. Sumber data penelitian berasal dari rekam medik pasien pada tahun 2018 – 2020. Didapatkan 53 pasien tuberkulosis dan 53 pasien koinfeksi tuberkulosis-HIV. Perbedaan nilai enzim hati (SGOT dan SGPT) dan derajat keparahan pada kedua kelompok tersebut dianalisis dengan uji Mann-Whitney dan Chi-Square. HASIL : Rata-rata nilai SGOT dan SGPT pada pasien koinfeksi tuberkulosis-HIV lebih tinggi dibandingkan pasien tanpa infeksi HIV, yaitu SGOT 127,1 µ/L dan SGPT 100,7 µ/L. Derajat keparahan tertinggi yang dialami pasien adalah grade 3 (hepatotoksik berat). Pasien koinfeksi tuberkulosis-HIV dengan derajat keparahan grade 3 sebanyak 22,6% dan pasien tuberkulosis sebanyak 9,4%. Nilai enzim hati maupun derajat keparahan hepatotoksik pada kedua kelompok pasien berbeda signfikan secara statistik dengan nilai p < 0,05. KESIMPULAN : Pasien koinfeksi tuberkulosis-HIV cenderung mengalami kejadian hepatotoksik terkait obat anti tuberkulosis lebih tinggi dibandingkan tanpa infeksi HIV.
Changes will occur in the human body with increasing age. Body changes arise from early life to old age in all organs and tissues. This condition can also be seen in the joint system associated with arthritis. The introduction of disease and arthritis treatment through extension methods needs to be done to the public to raise awareness of maintaining joint health. People who participate in this awareness-raising program are given pre and posttest related to the cause of arthritis, arthritis treatment, and how to take them appropriately to reduce the side effects of the drugs that can occur. Based on the analysis of the scores from the test, it was found that there was a significant increase in public knowledge before and after the program. The community also checks uric acid levels as an initial screening for gout signs, which is one of the most common arthritis in the community. Thus, the public has a better understanding of arthritis and joint health conditions based on examining uric acid levels.
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