BACKGROUND: Breast cancer (BC) is one of the most common types of cancer and the second leading cause of cancer death among women. Epidemiological studies showed that BC is linked to genetic and environmental factors, and inheritance plays a key role in the pathobiology of this disease. Interleukin 4 (IL-4) is a key differentiation cytokine and is produced by Th2 and activates Th2 development. Hence the current study aimed to assess the possible association between interleukin 4 (IL-4) VNTR polymorphism, and BC susceptibility in a sample of Iranian population. MATERIAL AND METHODS: IL-4 VNTR polymorphism was evaluated in 150 women with BC and 150 agematched healthy women by polymerase chain reaction method. RESULT: Among 3 possible alleles for IL-4 gene, we only observed 2 alleles. Current fi ndings indicate that RP2/RP2 genotypes can be regarded as potent protective factors against breast cancer (OR = 0.929 [95%CI, 0.929-0.995]). CONCLUSION: Our result showed that the RP2/RP2 genotype of the IL-4 VNTR polymorphism could be a protective factor for BC susceptibility (Tab. 2, Fig. 1, Ref. 46).
X-ray repair cross-complementing group 1 (XRCC1) is a scaffold protein and a key element in DNA base excision repair process. Although, the role of XRCC1 polymorphisms in male infertility has been studied broadly, it is still a matter of debate. Hence, in order to shed light on the problem, we performed a meta-analysis to evaluate the overall effect of XRCC1 polymorphisms in male infertility risk. Databases, Web of Science, PubMed, Scopus, and Google Scholar were searched until September 15, 2018. Afterwards, the genotypes' distribution, genotyping methods, and ethnicity groups were extracted, and overall analyses were conducted. A total number of fi ve researches on 1,407 subjects and 974 controls were found to meet our criteria in this meta-analysis. The XRCC1 Arg399Gln (rs25487) polymorphism was analyzed. This is the fi rst meta-analysis to investigate the association of XRCC1 polymorphisms (codon 399) and male infertility risk. Our results indicated that the XRCC1 Arg399Gln polymorphism was not associated with male infertility risk in the total studied populations (Tab. 2, Fig. 3, Ref. 26). Text in PDF www.elis.sk.
Breast cancer is one of the leading causes of cancer mortality. Growing evidence indicates that interleukins and its polymorphisms are involved in the pathogenesis of breast cancer. Variable number of tandem repeat (VNTR) polymorphism can affect transcription rate, mRNA stability and also the resulting protein expression and activity. Hence, present study aimed to assess the possible association between interleukin-1 receptor antagonist (IL-1Ra) VNTR polymorphism, and breast cancer susceptibility in Iranian population. A total of 300 Iranian individuals, 150 breast cancer patients and 150 age-matched healthy women, were included in this study. DNA extracted by salting out method and genotyping was done using the polymerase chain reaction. The frequency of the allele 2(5% vs. 22%) and the 2/2 genotype (22% vs. 46%) of IL-1Ra VNTR polymorphism was significantly higher in healthy control compared to breast cancer patient: therefore, A2 allele may play a protective role against breast cancer and its progression (p = .0001 and OR = 0.105, 95% CI: [0.044-0.248]). The allele 2 and 2/2 genotype of the IL-Ra VNTR polymorphism can be a protective factor against breast cancer susceptibility.
Background:
Single-nucleotide polymorphisms (SNPs) in genes responsible for coding microRNAs (miRNAs)
are shown to be crucial in progression of breast cancer (BC).
Objective:
The purpose of this meta-analysis is to obtain more definitive and reliable results due to the ambiguity and
inconsistency of the previous findings in this regard. This study aimed at clarifying the association of mir14a
polymorphisms with breast cancer.
Method:
We searched PubMed, EMBASE, Web of Science and Google Scholar databases for papers published before
August 10, 2019. Afterward, genotypes’ distribution, genotyping methods and ethnicity groups were extracted and Overall
analyses were conducted. A total number of seventeen researches on 7676 subjects and 7476 controls were found to meet
our criteria in this meta-analysis.
Results:
our observations confirmed the increased risk in breast cancer with rs 2910164 polymorphism in three genetic
models: allele contrast fixed genetic model, Recessive fixed genetic model and CC vs. GG genetic model (P value 0.0109,
0.0404 and 0.0019 respectively).
Conclusion:
the rs2910164 polymorphism is associated with increased breast cancer risk. We suggest that more
multicenter studies with larger samples investigate this matter to further clarify the association and verify our findings.
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