The polymorphism of XRCC1 Arg399Gln (rs25487) and male infertility risk: a meta-analysis of 1,407 cases and 974 control studies

Abstract

X-ray repair cross-complementing group 1 (XRCC1) is a scaffold protein and a key element in DNA base excision repair process. Although, the role of XRCC1 polymorphisms in male infertility has been studied broadly, it is still a matter of debate. Hence, in order to shed light on the problem, we performed a meta-analysis to evaluate the overall effect of XRCC1 polymorphisms in male infertility risk. Databases, Web of Science, PubMed, Scopus, and Google Scholar were searched until September 15, 2018. Afterwards, the genotypes' distribution, genotyping methods, and ethnicity groups were extracted, and overall analyses were conducted. A total number of fi ve researches on 1,407 subjects and 974 controls were found to meet our criteria in this meta-analysis. The XRCC1 Arg399Gln (rs25487) polymorphism was analyzed. This is the fi rst meta-analysis to investigate the association of XRCC1 polymorphisms (codon 399) and male infertility risk. Our results indicated that the XRCC1 Arg399Gln polymorphism was not associated with male infertility risk in the total studied populations (Tab. 2, Fig. 3, Ref. 26). Text in PDF www.elis.sk.

Association between X‐ray repair cross‐complementing group 1 Arg399Gln polymorphism and male infertility: An update meta‐analysis

“…Compared with two previous relative meta‐analyses (Ibrahimi et al., 2019; Singh, Bansal, et al, 2019), we added two new original articles (Akbas et al., 2019; Garcia‐Rodriguez, et al., 2018). In addition, we changed or deleted some papers which were included in previous studies.…”

“…The main controversy consisted in two papers (Gu et al., 2007; Ji et al., 2010). Ibrahimi et al (Ibrahimi et al., 2019) included both of the two papers; however, Singh, Bansal, et al (2019) excluded Ji's paper (Ji et al., 2010) because they thought that Ji's article aimed to study the joint effects of ERCC2 polymorphisms and polycyclic aromatic hydrocarbon exposure on male infertility. In our study, after reading the full text of Ji's research, we found that all the cases were recruited from regular patients and fertility males without any intervention such as whether cases were exposed in environmental pollution, indicating that Ji's paper fulfilled our inclusion criteria.…”

“…However, others found little statistic association between XRCC1 Arg399Gln and male infertility risk (Akbas, Balkan, Binici, & Gedik, 2019; Ji et al., 2010). Although two well‐designed meta‐analyses on this topic had been conducted in 2019 (Ibrahimi et al., 2019; Singh, Bansal, et al, 2019), more related articles were published thereafter. The conclusion remains inconsistent and controversial.…”

Investigation of oxidative stress status in cumulus cells in patıents with in vitro fertilization

“…Infertility is defined as inability to conceive naturally after one year of regular unprotected sexual intercourse [1]. Tubal factor, endometriosis, cervical factor, pelvic adhesion, male factor and unexplained infertility are among the main causes of infertility [2].…”