Faktor yang paling berpengaruh pada penuaan dini adalah radikal bebas. Penggunaan antioksidan dari terong ungu dan tomat merupakan salah satu cara melawan radikal bebas. Antioksidan tersebut dapat digunakan sebagai bahan aktif dalam produk kosmetik untuk memaksimalkan perawatan pencegahan penuaan. Penelitian ini bertujuan untuk mengoptimasi formula sediaan krim ekstrak terong ungu dan tomat dengan variasi nilai HLB kombinasi emulgator yaitu Span 60 dan Tween 80. Ekstrak diformulasikan ke dalam krim yang dibagi menjadi tiga formula yaitu formula 1, formula 2 dan formula 3 dengan nilai HLB berturut-turut 11,40; 9,34; dan 10,37. Penentuan stabilitas dan formula terbaik didapatkan dari evaluasi sediaan krim yang meliputi uji organoleptis, uji homogenitas fisik, uji pH, uji daya sebar, dan uji tipe emulsi. Analisis data penelitian ini menggunakan Uji ANOVA one way (p ≥ 0,05) untuk mengetahui adanya perbedaan daya sebar ketiga formula sediaan krim ekstrak terong ungu dan tomat. Hasil penelitian menunjukkan bahwa penggunaan emulgator kombinasi Span 60 dan Tween 80 dapat menghasilkan sediaan krim yang baik, tetapi formula 2 lebih menunjukkan konsistensi sediaan krim yang paling baik. Kesimpulan penelitian ini adalah krim dengan nilai HLB emulgator kombinasi Span 60 dan Tween 80 sebesar 9,34 lebih sesuai untuk formula sediaan krim dari ekstrak terong ungu dan tomat.Kata kunci: Krim Anti-aging; ekstrak kulit terong ungu; ekstrak tomat Abstract [Optimization of Anti-aging Cream Preparation Formula from Extracts of Purple Eggplant (Solanum melongena L.) and Tomatoes (Solanum lycopersicum L.)] The most influential factor in premature aging is free radicals. The use of antioxidants from purple eggplant and tomatoes is one way to fight free radicals. These antioxidants can be used as active ingredients in cosmetic products to maximize aging prevention treatments. This study aims to optimize the formula of purple eggplant and tomato extract cream with a variety of HLB values of emulgator combinations namely Span 60 and Tween 80. Extracts are formulated into creams which are divided into three formulas, formula 1, formula 2 and formula 3 with successive HLB values. 11.40; 9.34; and 10.37. Determination of the best stability and formula was obtained from evaluation of cream preparations which included organoleptic test, physical homogeneity test, pH test, dispersion test, and emulsion type test. Data analysis using ANOVA one way test (p ≥ 0,05) to determine the differences in the spread of the three formulas of purple eggplant and tomato extract cream preparations. The results showed that the use of Span 60 and Tween 80 combination emulgators could produce good cream preparations, but formula 2 showed the best consistency of cream preparations. The conclusion of this study is the cream with HLB value of combination Span 60 and Tween 80 emulgators of 9.34 is more suitable for cream preparation formulas from purple eggplant extract and tomatoes.
Premature rupture of membrane (PROM) is rupture of the membrane before the birth time. It can happen in the end of pregnancy as well as the early pregnancy (premature pregnancy). The incident of PROM at Denisa Public Hospital Gresik reach 31%. PROM is high risk pregnancy, it was caused of predisposition factors such as incompeten cervix, uterus overdistension, the abnormal position, CPD, and infection. The purpose of this research is to identify the correlation of characteristics with causes of PROM at Denisa Public Hospital Gresik.This research is using analytics method by using simple random sampling. The sampel has been taken of 59 respondents from 143 of population, it begining of march 2017 until march 2018. The variable of this research is characteristics and the causes of PROM. The measurement tools were used check list and data was analyzedusing chi square test with the alpha of 5%. The result showed that the factors that cause premature rupture of membranes in this study include: incompetent cervix, uterine overdistention, location abnormalities, CPD and infection. Maternal age correlates with incompetent cervical events, CPD and infections, while maternal work is associated with location abnormalities.So that risk screening at the beginning of pregnancy and routine ANC examination is very necessary. Abstrak: Ketuban Pecah Dini (KPD) adalah pecahnya selaput sebelum waktu kelahiran. Ini bisa terjadi pada akhir kehamilan maupun pada awal kehamilan (kehamilan prematur). Insiden KPD di Rumah Sakit Umum Denisa Gresik mencapai 31%. KPD merupakan kehamilan risiko tinggi, hal itu disebabkan oleh faktor predisposisi seperti inkompeten serviks, kelebihan rahim, posisi abnormal, CPD, dan infeksi. Tujuan dari penelitian ini adalah untuk mengidentifikasi hubungan karakteristik dengan penyebab KPD di Rumah Sakit Umum Denisa Gresik. Penelitian ini menggunakan metode analitik dengan menggunakan simple random sampling. Sampel telah diambil sejumlah 59 responden dari 143 populasi, mulai dari Maret 2017 hingga Maret 2018. Variabel penelitian ini adalah karakteristik dan penyebab KPD. Alat ukur digunakan adalah checklist dan data dianalisis menggunakan uji chi square dengan alpha 5%. Faktor penyebab ketuban pecah dini dalam penelitian ini meliputi : serviks inkompeten, overdistensi uterus, kelainan letak, CPD, dan infeksi. Umur ibu berkorelasi dengan kejadian serviks inkompeten, CPD, dan Infeksi, sedangkan pekerjaan ibu berhubungan dengan kelainan letak. Sehingga skrining risiko saat awal kehamilan dan pemeriksaan ANC rutin sangat diperlukan.
Introduction: Tinospora crispa (T. crispa) is an herbaceous plant that commonly grows wild in tropical regions of South East Asian countries such as Indonesia, Malaysia, and Thailand. In Indonesia, this plant is well known to be used as a traditional medicine to treat gout, diabetes, hypertension, rheumatic, fever, and appetite stimulant. Researches worldwide indicate that T. crispa poses several pharmacological properties. One of those is the antioxidant activity, acting as a free radical scavenger. The objective of this study was to determine the antioxidative properties of T. crispa and to compare the different ethanol solvents used for extraction. Methods: The amount of 300 g T. crispa powder was extracted using 70%, 80%, and 96% ethanol. The spectrophotometry method is used to assess the total flavonoid and polyphenol contents as well athe s DPPH assay. Results: The 80% ethanol had the highest flavonoid content 0.090% ± [0.453%], while 96% ethanol indicated the lowest 0.038% ± [3.090%]. In the case of phenolic content, 96% ethanol showed the highest result 0.521 ± [11.341%]. However, this value was relatively comparable with the other solvents. The highest DPPH activity was shown by 80% ethanol 6.46 mg ± [3.04 mg]. Conclusion: Despite low in the concentration, flavonoid and polyphenol content was successfully determined from T. crispa by using different ethanol solvents. Based on the result of antioxidants concentration and activity, 80% ethanol is the most ideal solvent to be used for extraction of T. crispa.
Background: Turmeric is a plant that grows in tropical areas and functions as medicine. The chemical compounds contained in turmeric have a role as antioxidants, antimicrobials, anti-cancer, indigestion, smallpox, insect bites. The curcumin content in turmeric has antibacterial activity against various types of Gram negative, Gram positive, antiviral and anti-tumor bacteria. Essential oils can be used as antibacterial because they contain hydroxyl and carbonyl functional groups which are phenol derivatives. Flavonoids can interfere with cell wall formation with peptidoglycan transpeptidase activity which will break down cell walls and damage cell membranes so that important components such as proteins, nucleic acids, nucleotides will be lysis. Staphylococcus bacteria are normal flora on the skin, respiratory tract, and digestive tract of food in humans. These bacteria can cause disease when they reach 1,000,000 or 106 per gram, an amount sufficient to produce the toxin. S. aureus bacteria can cause various types of infections ranging from minor skin infections, food poisoning to systemic infections. The aim of our study was to analyze the effects of infusion and turmeric juice (Curcuma domestica val) on the growth of bacteria Staphylococcus aureus through invitro. Method: This study is a laboratory experimental study with the aim of analyzing turmeric infusion (Curcuma domestica val) and turmeric juice effect on the growth of staphylococcus aureus by invitro. This research was conducted in an integrated laboratory, FK UNUSA. The samples in this study were 4 replications per treatment. The independent variables in this study were turmeric infusion and turmeric juice (with a concentration of 10%, 30%, 50% while the dependent variable in this study was the growth of Staphylococcus aureus bacteria. Data analysis used was the one way ANOVA test and Pearson correlation to determine the effect of giving turmeric infusion and turmeric juice on the growth of bacteria staphylococcus aureus through invitro. Result: The average growth of bacteria in the turmeric infusion in group I (control), 10%, 30% and 50% of turmeric infusion was 4.89 ± 0.4425 log CFU / ml, 3.07 ± 0.61330 log CFU / ml, 2.99 ± 0.63986 log CFU. / ml and 3.02 ± 0.22650 log CFU / ml. The average growth of this bacteria in giving turmeric juice in group I (control), giving 10%, 30% and 50% turmeric infusion was 4.89 ± 0.04425 log CFU / ml, 4.40 ± 0.18355log CFU / ml, 3.10 ± 0.58926 log CFU / ml and 3.02 ± 0.38206 log CFU / ml. Conclusion: In this study, found that there was an effect of giving turmeric infusion and turmeric juice (Curcuma domestica val) on Staphylococcus aureus growth and there was an effect of giving multilevel doses of turmeric infusion and turmeric juice (Curcuma domestica val) on Staphylococcus aureus growth through invitro.
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