Tujuan: Mengumpulkan informasi mengenai penanganan dan komplikasi diabetes, serta kesadaran pengendalian diri sendiri penderita diabetes di Indonesia. Studi ini juga mengevaluasi perspektif dokter, aspek psikologis, dan kualitas hidup pasien. Metode: Studi non-intervensi, potong lintang, merekrut 1832 pasien dari pusat kesehatan sekunder dan tersier di Indonesia. Data mengenai demografi , riwayat medis, faktor resiko, dan laporan pemeriksaan klinis termasuk laboratorium dikumpulkan dari rekam medis pasien. Sampel darah dikumpulkan untuk pengukuran HbA1c yang tersentralisasi.

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Metformin (MET) has possibilities to be utilized as an adjunct of tuberculosis (TB) therapy for controlling the growth of Mycobacterium tuberculosis (M. tuberculosis). MET enhances the production of mitochondrial reactive oxygen species and facilitates phagosome-lysosome fusion; those mechanism are important in M. tuberculosis elimination. Moreover, MET-associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB coinfection remains unknown. This result contributes much to our understanding about the clinical effect of MET use in type 2 DM-TB coinfection. For the purpose of understanding the MET effect as an adjuvant therapy in TB therapy and insulin simultaneous therapy, an observational clinical study was done in type 2 DM newly TB coinfection outpatients at Surabaya Paru Hospital. Patients were divided into two groups. First group was MET group, in which the patients were given MET accompanying insulin and TB treatment regimens, the golden standard therapy of DM-TB coinfection. MET therapy was given for at least 2 months. Second group was non-MET group, in which the patients were given insulin and TB treatment regimens. The lactate levels in both groups were measured after 2 months. Among 42 participants, there was no case of lactic acidosis during this study period. Data were normally distributed; thus, we continued analysis of the difference using paired T-test with 95% confidence. There was no difference in lactate levels (p=0.396) after MET therapy compared to non-MET group. In this study involving patients with TB pulmonary diseases, there is neither evidence that MET therapy induced lactic acidosis event nor that it increased lactate blood level. Thus, we concluded that MET use in type 2 DM-TB coinfection did not induce lactic acidosis.

Kendali glikemik merupakan hal yang penting bagi penyandang Diabetes Melitus (DM) karena berimplikasi terhadap upaya pengelolaan DM. Tuberkulosis (TB) paru merupakan salah satu komplikasi yang banyak pada pasien DM yang berhubungan dengan proses dan hasil pengobatan penyakit tersebut. Penelitian bertujuan mengetahui kendali glikemik berdasarkan parameter kadar Glukosa Darah Puasa (GDP), glukosa darah 2 jam post prandial (GD2JPP) dan HbA1c pada pasien diabetes melitus tipe 2 (DMT2) yang mengalami TB paru. Penelitian potong-lintang dilakukan pada 45 subyek DMT2 dengan TB paru dan 45 subyek DMT2 tanpa TB paru yang berobat jalan di dua rumah sakit di Surabaya. Hasil pemeriksaan GDP, GD2JPP, dan HbA1c yang dianalisis secara deskriptif, ditampilkan berupa nilai rerata dan Standar Deviasi (SD). Diperoleh rerata dan SD adalah GDP (202,11 ± 78,68 mg/dl), GD2JPP (283,20 ± 107,20 mg/dl), dan HbA1c (11,20 ± 2,61%) pada subyek DMT2 dengan TB paru sedangkan pada subyek DMT2 tanpa TB paru diperoleh GDP (175,29 ± 61,38 mg/dl), GD2JPP (208,22 ± 75,60 mg/dl), dan HbA1c (9,34 ± 2,22%). Nilai rerata GDP, GD2JPP dan HbA1c pasien DMT2 dengan TB paru lebih tinggi daripada DMT2 tanpa TB paru. Hal ini menunjukkan kriteria pengendalian DM yang belum mencapai sasaran sehingga perlu dilakukan upaya pemantauan kendali glikemik yang lebih baik

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Prediabetes is an intermediate metabolic state between normoglycaemia and diabetes, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and mildly raised haemoglobin A1c (HbA1c). Recent evidence has shown that individuals with prediabetes may have a higher prevalence of diabetes-associated complications than those with normal glucose levels. The risk of macrovascular and microvascular complications increases as early as in the state of prediabetes. Accumulating evidence demonstrated that prediabetes impair the physiological function and increase the risk of silent myocardial infarction, 1 stroke, 2 retinopathy, 3 cancer 4 and cognitive function. 5 Western Pacific region (including East Asia, South Asia, Northeast Asia and Southeast Asia) is the region with the most